Cobos EJ - Search Results

1

Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists.

Pasquinucci L, Parenti C, Ruiz-Cantero MC, Georgoussi Z, Pallaki P, Cobos EJ, Amata E, Marrazzo A, Prezzavento O, Arena E, Dichiara M, Salerno L, Turnaturi R. Pasquinucci L, et al. Among authors: cobos ej. ACS Med Chem Lett. 2020 Jan 28;11(5):678-685. doi: 10.1021/acsmedchemlett.9b00549. eCollection 2020 May 14. ACS Med Chem Lett. 2020. PMID: 32435370 Free PMC article.

2

Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties.

Marrazzo A, Cobos EJ, Parenti C, Aricò G, Marrazzo G, Ronsisvalle S, Pasquinucci L, Prezzavento O, Colabufo NA, Contino M, González LG, Scoto GM, Ronsisvalle G. Marrazzo A, et al. Among authors: cobos ej. J Med Chem. 2011 May 26;54(10):3669-73. doi: 10.1021/jm200144j. Epub 2011 Apr 21. J Med Chem. 2011. PMID: 21476493

3

(+)-and (-)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/σ₁ antagonist properties and antinociceptive effects.

Prezzavento O, Arena E, Sánchez-Fernández C, Turnaturi R, Parenti C, Marrazzo A, Catalano R, Amata E, Pasquinucci L, Cobos EJ. Prezzavento O, et al. Among authors: cobos ej. Eur J Med Chem. 2017 Jan 5;125:603-610. doi: 10.1016/j.ejmech.2016.09.077. Epub 2016 Sep 26. Eur J Med Chem. 2017. PMID: 27721146

4

Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice.

Tejada MA, Montilla-García A, Cronin SJ, Cikes D, Sánchez-Fernández C, González-Cano R, Ruiz-Cantero MC, Penninger JM, Vela JM, Baeyens JM, Cobos EJ. Tejada MA, et al. Among authors: cobos ej. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8396-8401. doi: 10.1073/pnas.1620068114. Epub 2017 Jul 17. Proc Natl Acad Sci U S A. 2017. PMID: 28716934 Free PMC article.

5

(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties.

Amata E, Rescifina A, Prezzavento O, Arena E, Dichiara M, Pittalà V, Montilla-García Á, Punzo F, Merino P, Cobos EJ, Marrazzo A. Amata E, et al. Among authors: cobos ej. J Med Chem. 2018 Jan 11;61(1):372-384. doi: 10.1021/acs.jmedchem.7b01584. Epub 2017 Dec 20. J Med Chem. 2018. PMID: 29220177

6

Targeting immune-driven opioid analgesia by sigma-1 receptors: Opening the door to novel perspectives for the analgesic use of sigma-1 antagonists.

Tejada MÁ, Montilla-García Á, González-Cano R, Bravo-Caparrós I, Ruiz-Cantero MC, Nieto FR, Cobos EJ. Tejada MÁ, et al. Among authors: cobos ej. Pharmacol Res. 2018 May;131:224-230. doi: 10.1016/j.phrs.2018.02.008. Epub 2018 Feb 15. Pharmacol Res. 2018. PMID: 29454675 Free article. Review.

7

Modulation by Sigma-1 Receptor of Morphine Analgesia and Tolerance: Nociceptive Pain, Tactile Allodynia and Grip Strength Deficits During Joint Inflammation.

Montilla-García Á, Tejada MÁ, Ruiz-Cantero MC, Bravo-Caparrós I, Yeste S, Zamanillo D, Cobos EJ. Montilla-García Á, et al. Among authors: cobos ej. Front Pharmacol. 2019 Feb 22;10:136. doi: 10.3389/fphar.2019.00136. eCollection 2019. Front Pharmacol. 2019. PMID: 30853912 Free PMC article.

8

The search for translational pain outcomes to refine analgesic development: Where did we come from and where are we going?

González-Cano R, Montilla-García Á, Ruiz-Cantero MC, Bravo-Caparrós I, Tejada MÁ, Nieto FR, Cobos EJ. González-Cano R, et al. Among authors: cobos ej. Neurosci Biobehav Rev. 2020 Jun;113:238-261. doi: 10.1016/j.neubiorev.2020.03.004. Epub 2020 Mar 5. Neurosci Biobehav Rev. 2020. PMID: 32147529 Review.

9

Sigma-1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury.

Bravo-Caparrós I, Ruiz-Cantero MC, Perazzoli G, Cronin SJF, Vela JM, Hamed MF, Penninger JM, Baeyens JM, Cobos EJ, Nieto FR. Bravo-Caparrós I, et al. Among authors: cobos ej. FASEB J. 2020 Apr;34(4):5951-5966. doi: 10.1096/fj.201901921R. Epub 2020 Mar 10. FASEB J. 2020. PMID: 32157739

10

Sigma-1 receptor: A drug target for the modulation of neuroimmune and neuroglial interactions during chronic pain.

Ruiz-Cantero MC, González-Cano R, Tejada MÁ, Santos-Caballero M, Perazzoli G, Nieto FR, Cobos EJ. Ruiz-Cantero MC, et al. Among authors: cobos ej. Pharmacol Res. 2021 Jan;163:105339. doi: 10.1016/j.phrs.2020.105339. Epub 2020 Dec 1. Pharmacol Res. 2021. PMID: 33276102 Free article. Review.

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