Leighton B - Search Results

1

Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model.

Fromont C, Atzori A, Kaur D, Hashmi L, Greco G, Cabanillas A, Nguyen HV, Jones DH, Garzón M, Varela A, Stevenson B, Iacobini GP, Lenoir M, Rajesh S, Box C, Kumar J, Grant P, Novitskaya V, Morgan J, Sorrell FJ, Redondo C, Kramer A, Harris CJ, Leighton B, Vickers SP, Cheetham SC, Kenyon C, Grabowska AM, Overduin M, Berditchevski F, Weston CJ, Knapp S, Fischer PM, Butterworth S. Fromont C, et al. Among authors: leighton b. J Med Chem. 2020 Jul 9;63(13):6784-6801. doi: 10.1021/acs.jmedchem.9b01803. Epub 2020 Jun 22. J Med Chem. 2020. PMID: 32433887 Free PMC article.

2

Effects of hypothyroidism on the sensitivity of glycolysis and glycogen synthesis to insulin in the soleus muscle of the rat.

Dimitriadis GD, Leighton B, Parry-Billings M, West D, Newsholme EA. Dimitriadis GD, et al. Among authors: leighton b. Biochem J. 1989 Jan 15;257(2):369-73. doi: 10.1042/bj2570369. Biochem J. 1989. PMID: 2649073 Free PMC article.

3

Effects of hyperthyroidism on the sensitivity of glycolysis and glycogen synthesis to insulin in the soleus muscle of the rat.

Dimitriadis GD, Leighton B, Vlachonikolis IG, Parry-Billings M, Challiss RA, West D, Newsholme EA. Dimitriadis GD, et al. Among authors: leighton b. Biochem J. 1988 Jul 1;253(1):87-92. doi: 10.1042/bj2530087. Biochem J. 1988. PMID: 3048254 Free PMC article.

4

Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro.

Leighton B, Cooper GJ. Leighton B, et al. Nature. 1988 Oct 13;335(6191):632-5. doi: 10.1038/335632a0. Nature. 1988. PMID: 3050530

5

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors still improve metabolic phenotype in male 11β-HSD1 knockout mice suggesting off-target mechanisms.

Harno E, Cottrell EC, Yu A, DeSchoolmeester J, Gutierrez PM, Denn M, Swales JG, Goldberg FW, Bohlooly-Y M, Andersén H, Wild MJ, Turnbull AV, Leighton B, White A. Harno E, et al. Among authors: leighton b. Endocrinology. 2013 Dec;154(12):4580-93. doi: 10.1210/en.2013-1613. Epub 2013 Oct 29. Endocrinology. 2013. PMID: 24169553 Free PMC article.

6

Effects of prolonged elevation of plasma adrenaline concentration in vivo on insulin-sensitivity in soleus muscle of the rat.

Budohoski L, Challiss RA, Dubaniewicz A, Kaciuba-Usciłko H, Leighton B, Lozeman FJ, Nazar K, Newsholme EA, Porta S. Budohoski L, et al. Among authors: leighton b. Biochem J. 1987 Jun 15;244(3):655-60. doi: 10.1042/bj2440655. Biochem J. 1987. PMID: 3328612 Free PMC article.

7

The role of prostaglandins as modulators of insulin-stimulated glucose metabolism in skeletal muscle.

Leighton B, Challiss RA, Newsholme EA. Leighton B, et al. Horm Metab Res Suppl. 1990;22:89-95. Horm Metab Res Suppl. 1990. PMID: 1697277

8

Effects of the diuretic furosemide on the sensitivity of glycolysis and glycogen synthesis to insulin in the soleus muscle of the rat.

Dimitriadis G, Leighton B, Parry-Billings M, Newsholme EA. Dimitriadis G, et al. Among authors: leighton b. Diabetologia. 1988 Jan;31(1):58-61. doi: 10.1007/BF00279135. Diabetologia. 1988. PMID: 3280371

9

Phosphorylation of hexokinase in insulin resistance.

Sanderson AL, Radda GK, Leighton B. Sanderson AL, et al. Among authors: leighton b. Biochem Soc Trans. 1997 Feb;25(1):68S. doi: 10.1042/bst025068s. Biochem Soc Trans. 1997. PMID: 9056966 No abstract available.

10

Effects of aging on the responsiveness and sensitivity of glucose metabolism to insulin in the incubated soleus muscle isolated from Sprague-Dawley and Wistar rats.

Leighton B, Dimitriadis GD, Parry-Billings M, Lozeman FJ, Newsholme EA. Leighton B, et al. Biochem J. 1989 Jul 15;261(2):383-7. doi: 10.1042/bj2610383. Biochem J. 1989. PMID: 2673220 Free PMC article.

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