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Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model.
Fromont C, Atzori A, Kaur D, Hashmi L, Greco G, Cabanillas A, Nguyen HV, Jones DH, Garzón M, Varela A, Stevenson B, Iacobini GP, Lenoir M, Rajesh S, Box C, Kumar J, Grant P, Novitskaya V, Morgan J, Sorrell FJ, Redondo C, Kramer A, Harris CJ, Leighton B, Vickers SP, Cheetham SC, Kenyon C, Grabowska AM, Overduin M, Berditchevski F, Weston CJ, Knapp S, Fischer PM, Butterworth S. Fromont C, et al. Among authors: kumar j. J Med Chem. 2020 Jul 9;63(13):6784-6801. doi: 10.1021/acs.jmedchem.9b01803. Epub 2020 Jun 22. J Med Chem. 2020. PMID: 32433887 Free PMC article.
Binding of the periplakin linker requires vimentin acidic residues D176 and E187.
Odintsova E, Mohammed F, Trieber C, Rodriguez-Zamora P, Al-Jassar C, Huang TH, Fogl C, Knowles T, Sridhar P, Kumar J, Jeeves M, Chidgey M, Overduin M. Odintsova E, et al. Among authors: kumar j. Commun Biol. 2020 Feb 21;3(1):83. doi: 10.1038/s42003-020-0810-y. Commun Biol. 2020. PMID: 32081916 Free PMC article.
Backbone resonance assignments of the catalytic and regulatory domains of Ca2+/calmodulin-dependent protein kinase 1D.
Tong MHG, Jeeves M, Rajesh S, Ludwig C, Lenoir M, Kumar J, McClelland DM, Berditchevski F, Hubbard JA, Kenyon C, Butterworth S, Knapp S, Overduin M. Tong MHG, et al. Among authors: kumar j. Biomol NMR Assign. 2020 Oct;14(2):221-225. doi: 10.1007/s12104-020-09950-x. Epub 2020 Jun 13. Biomol NMR Assign. 2020. PMID: 32535836 Free PMC article.
2,570 results