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Hypoxia-inducible factor 2α drives hepatosteatosis through the fatty acid translocase CD36.
Rey E, Meléndez-Rodríguez F, Marañón P, Gil-Valle M, Carrasco AG, Torres-Capelli M, Chávez S, Del Pozo-Maroto E, Rodríguez de Cía J, Aragonés J, García-Monzón C, González-Rodríguez Á. Rey E, et al. Among authors: aragones j. Liver Int. 2020 Oct;40(10):2553-2567. doi: 10.1111/liv.14519. Epub 2020 Jun 10. Liver Int. 2020. PMID: 32432822 Free PMC article.
HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5.
Elorza A, Soro-Arnáiz I, Meléndez-Rodríguez F, Rodríguez-Vaello V, Marsboom G, de Cárcer G, Acosta-Iborra B, Albacete-Albacete L, Ordóñez A, Serrano-Oviedo L, Giménez-Bachs JM, Vara-Vega A, Salinas A, Sánchez-Prieto R, Martín del Río R, Sánchez-Madrid F, Malumbres M, Landázuri MO, Aragonés J. Elorza A, et al. Among authors: aragones j. Mol Cell. 2012 Dec 14;48(5):681-91. doi: 10.1016/j.molcel.2012.09.017. Epub 2012 Oct 25. Mol Cell. 2012. PMID: 23103253 Free article.
Role of Mitochondrial Complex IV in Age-Dependent Obesity.
Soro-Arnaiz I, Li QOY, Torres-Capelli M, Meléndez-Rodríguez F, Veiga S, Veys K, Sebastian D, Elorza A, Tello D, Hernansanz-Agustín P, Cogliati S, Moreno-Navarrete JM, Balsa E, Fuertes E, Romanos E, Martínez-Ruiz A, Enriquez JA, Fernandez-Real JM, Zorzano A, De Bock K, Aragonés J. Soro-Arnaiz I, et al. Among authors: aragones j. Cell Rep. 2016 Sep 13;16(11):2991-3002. doi: 10.1016/j.celrep.2016.08.041. Cell Rep. 2016. PMID: 27626667 Free article.
CD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes.
Labiano S, Meléndez-Rodríguez F, Palazón A, Teijeira Á, Garasa S, Etxeberria I, Aznar MÁ, Sánchez-Paulete AR, Azpilikueta A, Bolaños E, Molina C, de la Fuente H, Maiso P, Sánchez-Madrid F, de Landázuri MO, Aragonés J, Melero I. Labiano S, et al. Among authors: aragones j. Oncoimmunology. 2017 Jan 19;6(4):e1283468. doi: 10.1080/2162402X.2017.1283468. eCollection 2017. Oncoimmunology. 2017. PMID: 28507790 Free PMC article.
HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis.
Meléndez-Rodríguez F, Urrutia AA, Lorendeau D, Rinaldi G, Roche O, Böğürcü-Seidel N, Ortega Muelas M, Mesa-Ciller C, Turiel G, Bouthelier A, Hernansanz-Agustín P, Elorza A, Escasany E, Li QOY, Torres-Capelli M, Tello D, Fuertes E, Fraga E, Martínez-Ruiz A, Pérez B, Giménez-Bachs JM, Salinas-Sánchez AS, Acker T, Sánchez Prieto R, Fendt SM, De Bock K, Aragonés J. Meléndez-Rodríguez F, et al. Among authors: aragones j. Cell Rep. 2019 Feb 26;26(9):2257-2265.e4. doi: 10.1016/j.celrep.2019.01.106. Cell Rep. 2019. PMID: 30811976 Free article.
Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors.
Moreno-Domínguez A, Ortega-Sáenz P, Gao L, Colinas O, García-Flores P, Bonilla-Henao V, Aragonés J, Hüttemann M, Grossman LI, Weissmann N, Sommer N, López-Barneo J. Moreno-Domínguez A, et al. Among authors: aragones j. Sci Signal. 2020 Jan 21;13(615):eaay9452. doi: 10.1126/scisignal.aay9452. Sci Signal. 2020. PMID: 31848220 Free article.
169 results