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Resistance to the "last resort" antibiotic colistin: a single-zinc mechanism for phosphointermediate formation in MCR enzymes.
Lythell E, Suardíaz R, Hinchliffe P, Hanpaibool C, Visitsatthawong S, Oliveira ASF, Lang EJM, Surawatanawong P, Lee VS, Rungrotmongkol T, Fey N, Spencer J, Mulholland AJ. Lythell E, et al. Among authors: hinchliffe p. Chem Commun (Camb). 2020 Jun 23;56(50):6874-6877. doi: 10.1039/d0cc02520h. Chem Commun (Camb). 2020. PMID: 32432618
Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas maltophilia Clinical Isolates.
Calvopiña K, Umland KD, Rydzik AM, Hinchliffe P, Brem J, Spencer J, Schofield CJ, Avison MB. Calvopiña K, et al. Among authors: hinchliffe p. Antimicrob Agents Chemother. 2016 Jun 20;60(7):4170-5. doi: 10.1128/AAC.00371-16. Print 2016 Jul. Antimicrob Agents Chemother. 2016. PMID: 27139464 Free PMC article.
Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1.
Hinchliffe P, Yang QE, Portal E, Young T, Li H, Tooke CL, Carvalho MJ, Paterson NG, Brem J, Niumsup PR, Tansawai U, Lei L, Li M, Shen Z, Wang Y, Schofield CJ, Mulholland AJ, Shen J, Fey N, Walsh TR, Spencer J. Hinchliffe P, et al. Sci Rep. 2017 Jan 6;7:39392. doi: 10.1038/srep39392. Sci Rep. 2017. PMID: 28059088 Free PMC article.
Structural/mechanistic insights into the efficacy of nonclassical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates.
Calvopiña K, Hinchliffe P, Brem J, Heesom KJ, Johnson S, Cain R, Lohans CT, Fishwick CWG, Schofield CJ, Spencer J, Avison MB. Calvopiña K, et al. Among authors: hinchliffe p. Mol Microbiol. 2017 Nov;106(3):492-504. doi: 10.1111/mmi.13831. Epub 2017 Sep 21. Mol Microbiol. 2017. PMID: 28876489 Free article.
Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms.
Yang Q, Li M, Spiller OB, Andrey DO, Hinchliffe P, Li H, MacLean C, Niumsup P, Powell L, Pritchard M, Papkou A, Shen Y, Portal E, Sands K, Spencer J, Tansawai U, Thomas D, Wang S, Wang Y, Shen J, Walsh T. Yang Q, et al. Among authors: hinchliffe p. Nat Commun. 2017 Dec 12;8(1):2054. doi: 10.1038/s41467-017-02149-0. Nat Commun. 2017. PMID: 29233990 Free PMC article.
Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis.
Abboud MI, Kosmopoulou M, Krismanich AP, Johnson JW, Hinchliffe P, Brem J, Claridge TDW, Spencer J, Schofield CJ, Dmitrienko GI. Abboud MI, et al. Among authors: hinchliffe p. Chemistry. 2018 Apr 17;24(22):5734-5737. doi: 10.1002/chem.201705886. Epub 2018 Jan 17. Chemistry. 2018. PMID: 29250863 Free PMC article.
Structural and Kinetic Studies of the Potent Inhibition of Metallo-β-lactamases by 6-Phosphonomethylpyridine-2-carboxylates.
Hinchliffe P, Tanner CA, Krismanich AP, Labbé G, Goodfellow VJ, Marrone L, Desoky AY, Calvopiña K, Whittle EE, Zeng F, Avison MB, Bols NC, Siemann S, Spencer J, Dmitrienko GI. Hinchliffe P, et al. Biochemistry. 2018 Mar 27;57(12):1880-1892. doi: 10.1021/acs.biochem.7b01299. Epub 2018 Mar 9. Biochemistry. 2018. PMID: 29485857 Free PMC article.
84 results