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Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/MYC-signaling: effect on imatinib resistance and stem cells.
Clin Epigenetics. 2020 May 19;12(1):69. doi: 10.1186/s13148-020-00839-z.
Clin Epigenetics. 2020.
PMID: 32430012
Free PMC article.
HDAC6-an Emerging Target Against Chronic Myeloid Leukemia?
Losson H, Schnekenburger M, Dicato M, Diederich M.
Losson H, et al.
Cancers (Basel). 2020 Jan 29;12(2):318. doi: 10.3390/cancers12020318.
Cancers (Basel). 2020.
PMID: 32013157
Free PMC article.
Review.
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The HDAC6 inhibitor 7b induces BCR-ABL ubiquitination and downregulation and synergizes with imatinib to trigger apoptosis in chronic myeloid leukemia.
Losson H, Gajulapalli SR, Lernoux M, Lee JY, Mazumder A, Gérard D, Seidel C, Hahn H, Christov C, Dicato M, Kirsch G, Han BW, Schnekenburger M, Diederich M.
Losson H, et al.
Pharmacol Res. 2020 Oct;160:105058. doi: 10.1016/j.phrs.2020.105058. Epub 2020 Jun 30.
Pharmacol Res. 2020.
PMID: 32619722
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Natural Compound Histone Deacetylase Inhibitors (HDACi): Synergy with Inflammatory Signaling Pathway Modulators and Clinical Applications in Cancer.
Losson H, Schnekenburger M, Dicato M, Diederich M.
Losson H, et al.
Molecules. 2016 Nov 23;21(11):1608. doi: 10.3390/molecules21111608.
Molecules. 2016.
PMID: 27886118
Free PMC article.
Review.
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