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A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells.
Xu S, Smothers JC, Rye D, Endapally S, Chen H, Li S, Liang G, Kinnebrew M, Rohatgi R, Posner BA, Radhakrishnan A. Xu S, et al. Among authors: rohatgi r. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2318024121. doi: 10.1073/pnas.2318024121. Epub 2024 Feb 8. Proc Natl Acad Sci U S A. 2024. PMID: 38330014 Free PMC article.
Direct ionic stress sensing and mitigation by the transcription factor NFAT5.
Khandwala CB, Sarkar P, Schmidt HB, Ma M, Kinnebrew M, Pusapati GV, Patel BB, Tillo D, Lebensohn AM, Rohatgi R. Khandwala CB, et al. Among authors: rohatgi r. bioRxiv [Preprint]. 2023 Sep 24:2023.09.23.559074. doi: 10.1101/2023.09.23.559074. bioRxiv. 2023. PMID: 37886503 Free PMC article. Preprint.
The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling.
Ng VH, Spencer Z, Neitzel LR, Nayak A, Loberg MA, Shen C, Kassel SN, Kroh HK, An Z, Anthony CC, Bryant JM, Lawson A, Goldsmith L, Benchabane H, Hansen AG, Li J, D'Souza S, Lebensohn AM, Rohatgi R, Weiss WA, Weiss VL, Williams C, Hong CC, Robbins DJ, Ahmed Y, Lee E. Ng VH, et al. Among authors: rohatgi r. Nat Commun. 2023 Oct 5;14(1):6173. doi: 10.1038/s41467-023-41836-z. Nat Commun. 2023. PMID: 37798301 Free PMC article.
The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6.
Spencer ZT, Ng VH, Benchabane H, Siddiqui GS, Duwadi D, Maines B, Bryant JM, Schwarzkopf A, Yuan K, Kassel SN, Mishra A, Pimentel A, Lebensohn AM, Rohatgi R, Gerber SA, Robbins DJ, Lee E, Ahmed Y. Spencer ZT, et al. Among authors: rohatgi r. Nat Commun. 2023 Oct 5;14(1):6174. doi: 10.1038/s41467-023-41843-0. Nat Commun. 2023. PMID: 37798281 Free PMC article.
164 results