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PI3 kinase inhibitor PI828 uncouples aminergic GPCRs and Ca2+ mobilization irrespectively of its primary target.
Biochim Biophys Acta Gen Subj. 2024 May 30:130649. doi: 10.1016/j.bbagen.2024.130649. Online ahead of print.
Biochim Biophys Acta Gen Subj. 2024.
PMID: 38823731
Calcium signaling mediated by aminergic GPCRs is impaired by the PI3K inhibitor LY294002 and its analog LY303511 in a PI3K-independent manner.
Kotova PD, Kochkina EN, Lyamin OO, Rogachevskaja OA, Korolenko NP, Ivashin DS, Bystrova MF, Enukashvily NI, Kolesnikov SS.
Kotova PD, et al. Among authors: lyamin oo.
Eur J Pharmacol. 2020 Aug 5;880:173182. doi: 10.1016/j.ejphar.2020.173182. Epub 2020 May 13.
Eur J Pharmacol. 2020.
PMID: 32416185
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