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A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila.
Achal M, Trujillo AS, Melkani GC, Farman GP, Ocorr K, Viswanathan MC, Kaushik G, Newhard CS, Glasheen BM, Melkani A, Suggs JA, Moore JR, Swank DM, Bodmer R, Cammarato A, Bernstein SI. Achal M, et al. Among authors: viswanathan mc. J Mol Biol. 2016 Jun 5;428(11):2446-2461. doi: 10.1016/j.jmb.2016.04.021. Epub 2016 Apr 20. J Mol Biol. 2016. PMID: 27107639 Free PMC article.
TNNT2 mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction.
Madan A, Viswanathan MC, Woulfe KC, Schmidt W, Sidor A, Liu T, Nguyen TH, Trinh B, Wilson C, Madathil S, Vogler G, O'Rourke B, Biesiadecki BJ, Tobacman LS, Cammarato A. Madan A, et al. Among authors: viswanathan mc. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18822-18831. doi: 10.1073/pnas.2001692117. Epub 2020 Jul 20. Proc Natl Acad Sci U S A. 2020. PMID: 32690703 Free PMC article.
Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in Drosophila.
Trujillo AS, Hsu KH, Puthawala J, Viswanathan MC, Loya A, Irving TC, Cammarato A, Swank DM, Bernstein SI. Trujillo AS, et al. Among authors: viswanathan mc. Mol Biol Cell. 2021 Aug 19;32(18):1690-1706. doi: 10.1091/mbc.E21-02-0088. Epub 2021 Jun 3. Mol Biol Cell. 2021. PMID: 34081531 Free PMC article.
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