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PET ligands [18F]LSN3316612 and [11C]LSN3316612 quantify O-linked-β-N-acetyl-glucosamine hydrolase in the brain.
Lu S, Haskali MB, Ruley KM, Dreyfus NJ, DuBois SL, Paul S, Liow JS, Morse CL, Kowalski A, Gladding RL, Gilmore J, Mogg AJ, Morin SM, Lindsay-Scott PJ, Ruble JC, Kant NA, Shcherbinin S, Barth VN, Johnson MP, Cuadrado M, Jambrina E, Mannes AJ, Nuthall HN, Zoghbi SS, Jesudason CD, Innis RB, Pike VW. Lu S, et al. Among authors: gladding rl. Sci Transl Med. 2020 May 13;12(543):eaau2939. doi: 10.1126/scitranslmed.aau2939. Sci Transl Med. 2020. PMID: 32404505 Free PMC article.
[carbonyl-11C]4-Fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([11C]FIMX) is an effective radioligand for PET imaging of metabotropic glutamate receptor 1 (mGluR1) in monkey brain.
Hong J, Lu S, Xu R, Liow JS, Woock AE, Jenko KJ, Gladding RL, Zoghbi SS, Innis RB, Pike VW. Hong J, et al. Among authors: gladding rl. Nucl Med Biol. 2015 Dec;42(12):967-74. doi: 10.1016/j.nucmedbio.2015.07.006. Epub 2015 Jul 23. Nucl Med Biol. 2015. PMID: 26320813 Free PMC article.
3-Substituted 1,5-Diaryl-1 H-1,2,4-triazoles as Prospective PET Radioligands for Imaging Brain COX-1 in Monkey. Part 2: Selection and Evaluation of [11C]PS13 for Quantitative Imaging.
Shrestha S, Singh P, Cortes-Salva MY, Jenko KJ, Ikawa M, Kim MJ, Kobayashi M, Morse CL, Gladding RL, Liow JS, Zoghbi SS, Fujita M, Innis RB, Pike VW. Shrestha S, et al. Among authors: gladding rl. ACS Chem Neurosci. 2018 Nov 21;9(11):2620-2627. doi: 10.1021/acschemneuro.8b00103. Epub 2018 Jun 13. ACS Chem Neurosci. 2018. PMID: 29792035 Free PMC article.
Evaluation of a PET Radioligand to Image O-GlcNAcase in Brain and Periphery of Rhesus Monkey and Knock-Out Mouse.
Paul S, Haskali MB, Liow JS, Zoghbi SS, Barth VN, Kolodrubetz MC, Bond MR, Morse CL, Gladding RL, Frankland MP, Kant N, Slieker L, Shcherbinin S, Nuthall HN, Zanotti-Fregonara P, Hanover JA, Jesudason C, Pike VW, Innis RB. Paul S, et al. Among authors: gladding rl. J Nucl Med. 2019 Jan;60(1):129-134. doi: 10.2967/jnumed.118.213231. Epub 2018 Sep 13. J Nucl Med. 2019. PMID: 30213846 Free PMC article.
[O-methyl-11C]N-(4-(4-(3-Chloro-2-methoxyphenyl)-piperazin-1-yl)butyl)-1H-indole-2-carboxamide ([11C]BAK4-51) Is an Efflux Transporter Substrate and Ineffective for PET Imaging of Brain D₃ Receptors in Rodents and Monkey.
Liow JS, Morse CL, Lu S, Frankland M, Tye GL, Zoghbi SS, Gladding RL, Shaik AB, Innis RB, Newman AH, Pike VW. Liow JS, et al. Among authors: gladding rl. Molecules. 2018 Oct 23;23(11):2737. doi: 10.3390/molecules23112737. Molecules. 2018. PMID: 30360553 Free PMC article.
Synthesis of [18F]PS13 and Evaluation as a PET Radioligand for Cyclooxygenase-1 in Monkey.
Taddei C, Morse CL, Kim MJ, Liow JS, Montero Santamaria J, Zhang A, Manly LS, Zanotti-Fregonara P, Gladding RL, Zoghbi SS, Innis RB, Pike VW. Taddei C, et al. Among authors: gladding rl. ACS Chem Neurosci. 2021 Feb 3;12(3):517-530. doi: 10.1021/acschemneuro.0c00737. Epub 2021 Jan 25. ACS Chem Neurosci. 2021. PMID: 33491441 Free PMC article.
Synthesis and evaluation of N-methyl and S-methyl 11C-labeled 6-methylthio-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridines as radioligands for imaging beta-amyloid plaques in Alzheimer's disease.
Cai L, Liow JS, Zoghbi SS, Cuevas J, Baetas C, Hong J, Shetty HU, Seneca NM, Brown AK, Gladding R, Temme SS, Herman MM, Innis RB, Pike VW. Cai L, et al. J Med Chem. 2008 Jan 10;51(1):148-58. doi: 10.1021/jm700970s. Epub 2007 Dec 14. J Med Chem. 2008. PMID: 18078311
39 results