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mRNA structure determines specificity of a polyQ-driven phase separation.
Langdon EM, Qiu Y, Ghanbari Niaki A, McLaughlin GA, Weidmann CA, Gerbich TM, Smith JA, Crutchley JM, Termini CM, Weeks KM, Myong S, Gladfelter AS. Langdon EM, et al. Among authors: mclaughlin ga. Science. 2018 May 25;360(6391):922-927. doi: 10.1126/science.aar7432. Epub 2018 Apr 12. Science. 2018. PMID: 29650703 Free PMC article.
Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid.
Iserman C, Roden CA, Boerneke MA, Sealfon RSG, McLaughlin GA, Jungreis I, Fritch EJ, Hou YJ, Ekena J, Weidmann CA, Theesfeld CL, Kellis M, Troyanskaya OG, Baric RS, Sheahan TP, Weeks KM, Gladfelter AS. Iserman C, et al. Among authors: mclaughlin ga. Mol Cell. 2020 Dec 17;80(6):1078-1091.e6. doi: 10.1016/j.molcel.2020.11.041. Epub 2020 Nov 27. Mol Cell. 2020. PMID: 33290746 Free PMC article.
Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures.
Roden CA, Dai Y, Giannetti CA, Seim I, Lee M, Sealfon R, McLaughlin GA, Boerneke MA, Iserman C, Wey SA, Ekena JL, Troyanskaya OG, Weeks KM, You L, Chilkoti A, Gladfelter AS. Roden CA, et al. Among authors: mclaughlin ga. Nucleic Acids Res. 2022 Aug 12;50(14):8168-8192. doi: 10.1093/nar/gkac596. Nucleic Acids Res. 2022. PMID: 35871289 Free PMC article.
Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate.
Iserman C, Roden C, Boerneke M, Sealfon R, McLaughlin G, Jungreis I, Park C, Boppana A, Fritch E, Hou YJ, Theesfeld C, Troyanskaya OG, Baric RS, Sheahan TP, Weeks K, Gladfelter AS. Iserman C, et al. bioRxiv [Preprint]. 2020 Jun 12:2020.06.11.147199. doi: 10.1101/2020.06.11.147199. bioRxiv. 2020. PMID: 32587965 Free PMC article. Preprint.
15 results