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Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells.
Elmansi AM, Hussein KA, Herrero SM, Periyasamy-Thandavan S, Aguilar-Pérez A, Kondrikova G, Kondrikov D, Eisa NH, Pierce JL, Kaiser H, Ding KH, Walker AL, Jiang X, Bollag WB, Elsalanty M, Zhong Q, Shi XM, Su Y, Johnson M, Hunter M, Reitman C, Volkman BF, Hamrick MW, Isales CM, Fulzele S, McGee-Lawrence ME, Hill WD. Elmansi AM, et al. Among authors: aguilar perez a. Bone Rep. 2020 Apr 23;12:100270. doi: 10.1016/j.bonr.2020.100270. eCollection 2020 Jun. Bone Rep. 2020. PMID: 32395570 Free PMC article.
Age-associated changes in microRNAs affect the differentiation potential of human mesenchymal stem cells: Novel role of miR-29b-1-5p expression.
Eisa NH, Sudharsan PT, Herrero SM, Herberg SA, Volkman BF, Aguilar-Pérez A, Kondrikov D, Elmansi AM, Reitman C, Shi X, Fulzele S, McGee-Lawrence ME, Isales CM, Hamrick MW, Johnson MH, Chen J, Hill WD. Eisa NH, et al. Among authors: aguilar perez a. Bone. 2021 Dec;153:116154. doi: 10.1016/j.bone.2021.116154. Epub 2021 Aug 14. Bone. 2021. PMID: 34403754 Free PMC article.
What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands.
Elmansi AM, Awad ME, Eisa NH, Kondrikov D, Hussein KA, Aguilar-Pérez A, Herberg S, Periyasamy-Thandavan S, Fulzele S, Hamrick MW, McGee-Lawrence ME, Isales CM, Volkman BF, Hill WD. Elmansi AM, et al. Among authors: aguilar perez a. Pharmacol Ther. 2019 Jun;198:90-108. doi: 10.1016/j.pharmthera.2019.02.005. Epub 2019 Feb 10. Pharmacol Ther. 2019. PMID: 30759373 Free PMC article. Review.
Meta-Analysis and Evidence Base for the Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells in Knee Cartilage Repair: Methodological Guidelines and Quality Assessment.
Awad ME, Hussein KA, Helwa I, Abdelsamid MF, Aguilar-Perez A, Mohsen I, Hunter M, Hamrick MW, Isales CM, Elsalanty M, Hill WD, Fulzele S. Awad ME, et al. Among authors: aguilar perez a. Stem Cells Int. 2019 Apr 7;2019:3826054. doi: 10.1155/2019/3826054. eCollection 2019. Stem Cells Int. 2019. PMID: 31089328 Free PMC article. Review.
Kynurenine inhibits autophagy and promotes senescence in aged bone marrow mesenchymal stem cells through the aryl hydrocarbon receptor pathway.
Kondrikov D, Elmansi A, Bragg RT, Mobley T, Barrett T, Eisa N, Kondrikova G, Schoeinlein P, Aguilar-Perez A, Shi XM, Fulzele S, Lawrence MM, Hamrick M, Isales C, Hill W. Kondrikov D, et al. Among authors: aguilar perez a. Exp Gerontol. 2020 Feb;130:110805. doi: 10.1016/j.exger.2019.110805. Epub 2019 Dec 5. Exp Gerontol. 2020. PMID: 31812582 Free PMC article.
Megakaryocytes promote osteoclastogenesis in aging.
Kanagasabapathy D, Blosser RJ, Maupin KA, Hong JM, Alvarez M, Ghosh J, Mohamad SF, Aguilar-Perez A, Srour EF, Kacena MA, Bruzzaniti A. Kanagasabapathy D, et al. Among authors: aguilar perez a. Aging (Albany NY). 2020 Jul 7;12(14):15121-15133. doi: 10.18632/aging.103595. Epub 2020 Jul 7. Aging (Albany NY). 2020. PMID: 32634116 Free PMC article.
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