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Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms.
Duarte DP, Lamontanara AJ, La Sala G, Jeong S, Sohn YK, Panjkovich A, Georgeon S, Kükenshöner T, Marcaida MJ, Pojer F, De Vivo M, Svergun D, Kim HS, Dal Peraro M, Hantschel O. Duarte DP, et al. Among authors: kukenshoner t. Nat Commun. 2020 May 8;11(1):2319. doi: 10.1038/s41467-020-16128-5. Nat Commun. 2020. PMID: 32385234 Free PMC article.
Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase.
Reckel S, Gehin C, Tardivon D, Georgeon S, Kükenshöner T, Löhr F, Koide A, Buchner L, Panjkovich A, Reynaud A, Pinho S, Gerig B, Svergun D, Pojer F, Güntert P, Dötsch V, Koide S, Gavin AC, Hantschel O. Reckel S, et al. Among authors: kukenshoner t. Nat Commun. 2017 Dec 13;8(1):2101. doi: 10.1038/s41467-017-02313-6. Nat Commun. 2017. PMID: 29235475 Free PMC article.
Unpaired Extracellular Cysteine Mutations of CSF3R Mediate Gain or Loss of Function.
Zhang H, Means S, Schultz AR, Watanabe-Smith K, Medeiros BC, Bottomly D, Wilmot B, McWeeney SK, Kükenshöner T, Hantschel O, Tyner JW. Zhang H, et al. Among authors: kukenshoner t. Cancer Res. 2017 Aug 15;77(16):4258-4267. doi: 10.1158/0008-5472.CAN-17-1052. Epub 2017 Jun 26. Cancer Res. 2017. PMID: 28652245 Free PMC article.
Analysis of selected and designed chimeric D- and L-α-helix assemblies.
Kükenshöner T, Hagemann UB, Wohlwend D, Räuber C, Baumann T, Keller S, Einsle O, Müller KM, Arndt KM. Kükenshöner T, et al. Biomacromolecules. 2014 Sep 8;15(9):3296-305. doi: 10.1021/bm5006883. Epub 2014 Aug 13. Biomacromolecules. 2014. PMID: 25072521