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Behavioural and pharmacological profiles of zebrafish administrated pyrrolidinyl benzodioxanes and prolinol aryl ethers with high affinity for heteromeric nicotinic acetylcholine receptors.
Braida D, Ponzoni L, Moretti M, Viani P, Pallavicini M, Bolchi C, Appiani R, Bavo F, Gotti C, Sala M. Braida D, et al. Among authors: bavo f. Psychopharmacology (Berl). 2020 Aug;237(8):2317-2326. doi: 10.1007/s00213-020-05536-6. Epub 2020 May 7. Psychopharmacology (Berl). 2020. PMID: 32382782 Free article.
From pyrrolidinyl-benzodioxane to pyrrolidinyl-pyridodioxanes, or from unselective antagonism to selective partial agonism at α4β2 nicotinic acetylcholine receptor.
Bolchi C, Bavo F, Gotti C, Fumagalli L, Fasoli F, Binda M, Mucchietto V, Sciaccaluga M, Plutino S, Fucile S, Pallavicini M. Bolchi C, et al. Among authors: bavo f. Eur J Med Chem. 2017 Jan 5;125:1132-1144. doi: 10.1016/j.ejmech.2016.10.048. Epub 2016 Oct 21. Eur J Med Chem. 2017. PMID: 27810599
Modifications at C(5) of 2-(2-Pyrrolidinyl)-Substituted 1,4-Benzodioxane Elicit Potent α4β2 Nicotinic Acetylcholine Receptor Partial Agonism with High Selectivity over the α3β4 Subtype.
Bavo F, Pallavicini M, Gotti C, Appiani R, Moretti M, Colombo SF, Pucci S, Viani P, Budriesi R, Renzi M, Fucile S, Bolchi C. Bavo F, et al. J Med Chem. 2020 Dec 24;63(24):15668-15692. doi: 10.1021/acs.jmedchem.0c01150. Epub 2020 Dec 16. J Med Chem. 2020. PMID: 33325696 Free article.
Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an α7-nAChR, α9-nAChR Antagonist and of a Pro-Oxidant Mitocan.
Bavo F, Pucci S, Fasoli F, Lammi C, Moretti M, Mucchietto V, Lattuada D, Viani P, De Palma C, Budriesi R, Corradini I, Dowell C, McIntosh JM, Clementi F, Bolchi C, Gotti C, Pallavicini M. Bavo F, et al. J Med Chem. 2018 Dec 13;61(23):10531-10544. doi: 10.1021/acs.jmedchem.8b01052. Epub 2018 Nov 26. J Med Chem. 2018. PMID: 30403486
Evidence of a dual mechanism of action underlying the anti-proliferative and cytotoxic effects of ammonium-alkyloxy-stilbene-based α7- and α9-nicotinic ligands on glioblastoma cells.
Pucci S, Bolchi C, Bavo F, Pallavicini M, De Palma C, Renzi M, Fucile S, Benfante R, Di Lascio S, Lattuada D, Bessereau JL, D'Alessandro M, Risson V, Zoli M, Clementi F, Gotti C. Pucci S, et al. Among authors: bavo f. Pharmacol Res. 2022 Jan;175:105959. doi: 10.1016/j.phrs.2021.105959. Epub 2021 Oct 28. Pharmacol Res. 2022. PMID: 34756924 Free article.
From 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624) to Selective Small-Molecule Antagonists of Human α9α10 Nicotinic Receptor by Modifications at the Ammonium Ethyl Residue.
Bavo F, Pallavicini M, Pucci S, Appiani R, Giraudo A, Eaton B, Lucero L, Gotti C, Moretti M, Whiteaker P, Bolchi C. Bavo F, et al. J Med Chem. 2022 Jul 28;65(14):10079-10097. doi: 10.1021/acs.jmedchem.2c00746. Epub 2022 Jul 14. J Med Chem. 2022. PMID: 35834819 Free PMC article.
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