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Preoperative N-terminal pro-B-type natriuretic peptide and myocardial injury after stopping or continuing renin-angiotensin system inhibitors in noncardiac surgery: a prespecified analysis of a phase 2 randomised controlled multicentre trial.
Gutierrez Del Arroyo A, Patel A, Abbott TEF, Begum S, Dias P, Somanath S, Middleditch A, Cleland S, Brealey D, Pearse RM, Ackland GL; SPACE trial investigators. Gutierrez Del Arroyo A, et al. Br J Anaesth. 2024 May;132(5):857-866. doi: 10.1016/j.bja.2024.01.010. Epub 2024 Feb 9. Br J Anaesth. 2024. PMID: 38341283 Free PMC article. Clinical Trial.
Single cell spatial analysis reveals inflammatory foci of immature neutrophil and CD8 T cells in COVID-19 lungs.
Weeratunga P, Denney L, Bull JA, Repapi E, Sergeant M, Etherington R, Vuppussetty C, Turner GDH, Clelland C, Woo J, Cross A, Issa F, de Andrea CE, Melero Bermejo I, Sims D, McGowan S, Zurke YX, Ahern DJ, Gamez EC, Whalley J, Richards D, Klenerman P, Monaco C, Udalova IA, Dong T, Antanaviciute A, Ogg G, Knight JC, Byrne HM, Taylor S, Ho LP. Weeratunga P, et al. Among authors: whalley j. Nat Commun. 2023 Nov 8;14(1):7216. doi: 10.1038/s41467-023-42421-0. Nat Commun. 2023. PMID: 37940670 Free PMC article.
Discontinuation vs. continuation of renin-angiotensin system inhibition before non-cardiac surgery: the SPACE trial.
Ackland GL, Patel A, Abbott TEF, Begum S, Dias P, Crane DR, Somanath S, Middleditch A, Cleland S, Gutierrez Del Arroyo A, Brealey D, Pearse RM; Stopping Perioperative ACE-inhibitors or angiotensin-II receptor blockers (SPACE) trial investigators. Ackland GL, et al. Eur Heart J. 2024 Apr 1;45(13):1146-1155. doi: 10.1093/eurheartj/ehad716. Eur Heart J. 2024. PMID: 37935833 Free PMC article. Clinical Trial.
A Transcriptomic Approach to Understand Patient Susceptibility to Pneumonia After Abdominal Surgery.
Torrance HD, Zhang P, Longbottom ER, Mi Y, Whalley JP, Allcock A, Kwok AJ, Cano-Gamez E, Geoghegan CG, Burnham KL, Antcliffe DB, Davenport EE, Pearse RM, O'Dwyer MJ, Hinds CJ, Knight JC, Gordon AC. Torrance HD, et al. Among authors: whalley jp. Ann Surg. 2024 Mar 1;279(3):510-520. doi: 10.1097/SLA.0000000000006050. Epub 2023 Jul 27. Ann Surg. 2024. PMID: 37497667 Free PMC article.
Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery.
Edwards MR, Forbes G, Walker N, Morton DG, Mythen MG, Murray D, Anderson I, Mihaylova B, Thomson A, Taylor M, Hollyman M, Phillips R, Young K, Kahan BC, Pearse RM, Grocott MPW; FLO-ELA investigators. Edwards MR, et al. Trials. 2023 May 6;24(1):313. doi: 10.1186/s13063-023-07275-3. Trials. 2023. PMID: 37149623 Free PMC article.
164 results