Szabo C - Search Results

1

Cystathionine-β-Synthase: Molecular Regulation and Pharmacological Inhibition.

Zuhra K, Augsburger F, Majtan T, Szabo C. Zuhra K, et al. Among authors: szabo c. Biomolecules. 2020 Apr 30;10(5):697. doi: 10.3390/biom10050697. Biomolecules. 2020. PMID: 32365821 Free PMC article. Review.

2

Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE).

Asimakopoulou A, Panopoulos P, Chasapis CT, Coletta C, Zhou Z, Cirino G, Giannis A, Szabo C, Spyroulias GA, Papapetropoulos A. Asimakopoulou A, et al. Among authors: szabo c. Br J Pharmacol. 2013 Jun;169(4):922-32. doi: 10.1111/bph.12171. Br J Pharmacol. 2013. PMID: 23488457 Free PMC article.

3

Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer.

Druzhyna N, Szczesny B, Olah G, Módis K, Asimakopoulou A, Pavlidou A, Szoleczky P, Gerö D, Yanagi K, Törö G, López-García I, Myrianthopoulos V, Mikros E, Zatarain JR, Chao C, Papapetropoulos A, Hellmich MR, Szabo C. Druzhyna N, et al. Among authors: szabo c. Pharmacol Res. 2016 Nov;113(Pt A):18-37. doi: 10.1016/j.phrs.2016.08.016. Epub 2016 Aug 10. Pharmacol Res. 2016. PMID: 27521834 Free PMC article.

4

Potential Pharmacological Chaperones for Cystathionine Beta-Synthase-Deficient Homocystinuria.

Majtan T, Pey AL, Gimenez-Mascarell P, Martínez-Cruz LA, Szabo C, Kožich V, Kraus JP. Majtan T, et al. Among authors: szabo c. Handb Exp Pharmacol. 2018;245:345-383. doi: 10.1007/164_2017_72. Handb Exp Pharmacol. 2018. PMID: 29119254 Review.

5

Potential role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H₂S) pathway in cancer cells.

Augsburger F, Szabo C. Augsburger F, et al. Among authors: szabo c. Pharmacol Res. 2020 Apr;154:104083. doi: 10.1016/j.phrs.2018.11.034. Epub 2018 Nov 27. Pharmacol Res. 2020. PMID: 30500457 Review.

6

Overproduction of H₂S, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome.

Panagaki T, Randi EB, Augsburger F, Szabo C. Panagaki T, et al. Among authors: szabo c. Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):18769-18771. doi: 10.1073/pnas.1911895116. Epub 2019 Sep 3. Proc Natl Acad Sci U S A. 2019. PMID: 31481613 Free PMC article.

7

The re-emerging pathophysiological role of the cystathionine-β-synthase - hydrogen sulfide system in Down syndrome.

Szabo C. Szabo C. FEBS J. 2020 Aug;287(15):3150-3160. doi: 10.1111/febs.15214. Epub 2020 Feb 3. FEBS J. 2020. PMID: 31955501 Free article. Review.

8

Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells.

Augsburger F, Randi EB, Jendly M, Ascencao K, Dilek N, Szabo C. Augsburger F, et al. Among authors: szabo c. Biomolecules. 2020 Mar 13;10(3):447. doi: 10.3390/biom10030447. Biomolecules. 2020. PMID: 32183148 Free PMC article.

9

Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation and Cellular Bioenergetics in Human Down Syndrome Fibroblasts.

Panagaki T, Randi EB, Szabo C. Panagaki T, et al. Among authors: szabo c. Biomolecules. 2020 Apr 23;10(4):653. doi: 10.3390/biom10040653. Biomolecules. 2020. PMID: 32340322 Free PMC article.

10

Screening of Heteroaromatic Scaffolds against Cystathionine Beta-Synthase Enables Identification of Substituted Pyrazolo[3,4-c]Pyridines as Potent and Selective Orthosteric Inhibitors.

Fantel AM, Myrianthopoulos V, Georgoulis A, Lougiakis N, Zantza I, Lamprinidis G, Augsburger F, Marakos P, Vorgias CE, Szabo C, Pouli N, Papapetropoulos A, Mikros E. Fantel AM, et al. Among authors: szabo c. Molecules. 2020 Aug 16;25(16):3739. doi: 10.3390/molecules25163739. Molecules. 2020. PMID: 32824311 Free PMC article.

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