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Antileishmanial Chemotherapy through Clemastine Fumarate Mediated Inhibition of the Leishmania Inositol Phosphorylceramide Synthase.
Mina JGM, Charlton RL, Alpizar-Sosa E, Escrivani DO, Brown C, Alqaisi A, Borsodi MPG, Figueiredo CP, de Lima EV, Dickie EA, Wei W, Coutinho-Silva R, Merritt A, Smith TK, Barrett MP, Rossi-Bergmann B, Denny PW, Steel PG. Mina JGM, et al. Among authors: steel pg. ACS Infect Dis. 2021 Jan 8;7(1):47-63. doi: 10.1021/acsinfecdis.0c00546. Epub 2020 Dec 8. ACS Infect Dis. 2021. PMID: 33291887 Free PMC article.
Chalcones identify cTXNPx as a potential antileishmanial drug target.
Escrivani DO, Charlton RL, Caruso MB, Burle-Caldas GA, Borsodi MPG, Zingali RB, Arruda-Costa N, Palmeira-Mello MV, de Jesus JB, Souza AMT, Abrahim-Vieira B, Freitag-Pohl S, Pohl E, Denny PW, Rossi-Bergmann B, Steel PG. Escrivani DO, et al. Among authors: steel pg. PLoS Negl Trop Dis. 2021 Nov 15;15(11):e0009951. doi: 10.1371/journal.pntd.0009951. eCollection 2021 Nov. PLoS Negl Trop Dis. 2021. PMID: 34780470 Free PMC article.
The Trypanosoma brucei sphingolipid synthase, an essential enzyme and drug target.
Mina JG, Pan SY, Wansadhipathi NK, Bruce CR, Shams-Eldin H, Schwarz RT, Steel PG, Denny PW. Mina JG, et al. Among authors: steel pg. Mol Biochem Parasitol. 2009 Nov;168(1):16-23. doi: 10.1016/j.molbiopara.2009.06.002. Epub 2009 Jun 21. Mol Biochem Parasitol. 2009. PMID: 19545591 Free article.
79 results