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Halting the vicious cycle within the multiple myeloma ecosystem: blocking JAM-A on bone marrow endothelial cells restores angiogenic homeostasis and suppresses tumor progression.
Solimando AG, Da Vià MC, Leone P, Borrelli P, Croci GA, Tabares P, Brandl A, Di Lernia G, Bianchi FP, Tafuri S, Steinbrunn T, Balduini A, Melaccio A, De Summa S, Argentiero A, Rauert-Wunderlich H, Frassanito MA, Ditonno P, Henke E, Klapper W, Ria R, Terragna C, Rasche L, Rosenwald A, Kortüm MK, Cavo M, Ribatti D, Racanelli V, Einsele H, Vacca A, Beilhack A. Solimando AG, et al. Among authors: steinbrunn t. Haematologica. 2021 Jul 1;106(7):1943-1956. doi: 10.3324/haematol.2019.239913. Haematologica. 2021. PMID: 32354870 Free PMC article.
RAL GTPases mediate multiple myeloma cell survival and are activated independently of oncogenic RAS.
Seibold M, Stühmer T, Kremer N, Mottok A, Scholz CJ, Schlosser A, Leich E, Holzgrabe U, Brünnert D, Barrio S, Kortüm MK, Solimando AG, Chatterjee M, Einsele H, Rosenwald A, Bargou RC, Steinbrunn T. Seibold M, et al. Among authors: steinbrunn t. Haematologica. 2020 Sep 1;105(9):2316-2326. doi: 10.3324/haematol.2019.223024. Haematologica. 2020. PMID: 33054056 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 31601693
The PI3K/Akt signaling pathway regulates the expression of Hsp70, which critically contributes to Hsp90-chaperone function and tumor cell survival in multiple myeloma.
Chatterjee M, Andrulis M, Stühmer T, Müller E, Hofmann C, Steinbrunn T, Heimberger T, Schraud H, Kressmann S, Einsele H, Bargou RC. Chatterjee M, et al. Among authors: steinbrunn t. Haematologica. 2013 Jul;98(7):1132-41. doi: 10.3324/haematol.2012.066175. Epub 2012 Oct 12. Haematologica. 2013. PMID: 23065523 Free PMC article.
PI3K-dependent multiple myeloma cell survival is mediated by the PIK3CA isoform.
Hofmann C, Stühmer T, Schmiedl N, Wetzker R, Mottok A, Rosenwald A, Langer C, Zovko J, Chatterjee M, Einsele H, Bargou RC, Steinbrunn T. Hofmann C, et al. Among authors: steinbrunn t. Br J Haematol. 2014 Aug;166(4):529-39. doi: 10.1111/bjh.12920. Epub 2014 Apr 26. Br J Haematol. 2014. PMID: 24766330 Free article.
A GRP78-Directed Monoclonal Antibody Recaptures Response in Refractory Multiple Myeloma with Extramedullary Involvement.
Rasche L, Menoret E, Dubljevic V, Menu E, Vanderkerken K, Lapa C, Steinbrunn T, Chatterjee M, Knop S, Düll J, Greenwood DL, Hensel F, Rosenwald A, Einsele H, Brändlein S. Rasche L, et al. Among authors: steinbrunn t. Clin Cancer Res. 2016 Sep 1;22(17):4341-9. doi: 10.1158/1078-0432.CCR-15-3111. Epub 2016 Mar 30. Clin Cancer Res. 2016. PMID: 27029491
IKZF1/3 and CRL4CRBN E3 ubiquitin ligase mutations and resistance to immunomodulatory drugs in multiple myeloma.
Barrio S, Munawar U, Zhu YX, Giesen N, Shi CX, Viá MD, Sanchez R, Bruins L, Demler T, Müller N, Haertle L, Garitano A, Steinbrunn T, Danhof S, Cuenca I, Barrio-Garcia C, Braggio E, Rosenwald A, Martinez-Lopez J, Rasche L, Raab MS, Stewart AK, Einsele H, Stühmer T, Kortüm KM. Barrio S, et al. Among authors: steinbrunn t. Haematologica. 2020 May;105(5):e237-e241. doi: 10.3324/haematol.2019.217943. Epub 2019 Sep 26. Haematologica. 2020. PMID: 31558666 Free PMC article. No abstract available.
Multiple myeloma is affected by multiple and heterogeneous somatic mutations in adhesion- and receptor tyrosine kinase signaling molecules.
Leich E, Weißbach S, Klein HU, Grieb T, Pischimarov J, Stühmer T, Chatterjee M, Steinbrunn T, Langer C, Eilers M, Knop S, Einsele H, Bargou R, Rosenwald A. Leich E, et al. Among authors: steinbrunn t. Blood Cancer J. 2013 Feb 8;3(2):e102. doi: 10.1038/bcj.2012.47. Blood Cancer J. 2013. PMID: 23396385 Free PMC article.
21 results