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Combining dehydration, construct optimization and improved data collection to solve the crystal structure of a CRM1-RanGTP-SPN1-Nup214 quaternary nuclear export complex.
Monecke T, Dickmanns A, Weiss MS, Port SA, Kehlenbach RH, Ficner R. Monecke T, et al. Among authors: port sa. Acta Crystallogr F Struct Biol Commun. 2015 Dec;71(Pt 12):1481-7. doi: 10.1107/S2053230X15021524. Epub 2015 Nov 18. Acta Crystallogr F Struct Biol Commun. 2015. PMID: 26625290 Free PMC article.
Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence.
Bonnin E, Cabochette P, Filosa A, Jühlen R, Komatsuzaki S, Hezwani M, Dickmanns A, Martinelli V, Vermeersch M, Supply L, Martins N, Pirenne L, Ravenscroft G, Lombard M, Port S, Spillner C, Janssens S, Roets E, Van Dorpe J, Lammens M, Kehlenbach RH, Ficner R, Laing NG, Hoffmann K, Vanhollebeke B, Fahrenkrog B. Bonnin E, et al. PLoS Genet. 2018 Dec 13;14(12):e1007845. doi: 10.1371/journal.pgen.1007845. eCollection 2018 Dec. PLoS Genet. 2018. PMID: 30543681 Free PMC article.
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