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FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.
Spiekerkoetter E, Tian X, Cai J, Hopper RK, Sudheendra D, Li CG, El-Bizri N, Sawada H, Haghighat R, Chan R, Haghighat L, de Jesus Perez V, Wang L, Reddy S, Zhao M, Bernstein D, Solow-Cordero DE, Beachy PA, Wandless TJ, Ten Dijke P, Rabinovitch M. Spiekerkoetter E, et al. J Clin Invest. 2013 Aug;123(8):3600-13. doi: 10.1172/JCI65592. Epub 2013 Jul 15. J Clin Invest. 2013. PMID: 23867624 Free PMC article.
Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension.
Sawada H, Saito T, Nickel NP, Alastalo TP, Glotzbach JP, Chan R, Haghighat L, Fuchs G, Januszyk M, Cao A, Lai YJ, Perez Vde J, Kim YM, Wang L, Chen PI, Spiekerkoetter E, Mitani Y, Gurtner GC, Sarnow P, Rabinovitch M. Sawada H, et al. Among authors: spiekerkoetter e. J Exp Med. 2014 Feb 10;211(2):263-80. doi: 10.1084/jem.20111741. Epub 2014 Jan 20. J Exp Med. 2014. PMID: 24446489 Free PMC article.
Current clinical management of pulmonary arterial hypertension.
Zamanian RT, Kudelko KT, Sung YK, Perez VJ, Liu J, Spiekerkoetter E. Zamanian RT, et al. Among authors: spiekerkoetter e. Circ Res. 2014 Jun 20;115(1):131-147. doi: 10.1161/CIRCRESAHA.115.303827. Circ Res. 2014. PMID: 24951763 Free PMC article. Review.
RNA Sequencing Analysis Detection of a Novel Pathway of Endothelial Dysfunction in Pulmonary Arterial Hypertension.
Rhodes CJ, Im H, Cao A, Hennigs JK, Wang L, Sa S, Chen PI, Nickel NP, Miyagawa K, Hopper RK, Tojais NF, Li CG, Gu M, Spiekerkoetter E, Xian Z, Chen R, Zhao M, Kaschwich M, Del Rosario PA, Bernstein D, Zamanian RT, Wu JC, Snyder MP, Rabinovitch M. Rhodes CJ, et al. Among authors: spiekerkoetter e. Am J Respir Crit Care Med. 2015 Aug 1;192(3):356-66. doi: 10.1164/rccm.201408-1528OC. Am J Respir Crit Care Med. 2015. PMID: 26030479 Free PMC article.
FHIT, a Novel Modifier Gene in Pulmonary Arterial Hypertension.
Dannewitz Prosseda S, Tian X, Kuramoto K, Boehm M, Sudheendra D, Miyagawa K, Zhang F, Solow-Cordero D, Saldivar JC, Austin ED, Loyd JE, Wheeler L, Andruska A, Donato M, Wang L, Huebner K, Metzger RJ, Khatri P, Spiekerkoetter E. Dannewitz Prosseda S, et al. Among authors: spiekerkoetter e. Am J Respir Crit Care Med. 2019 Jan 1;199(1):83-98. doi: 10.1164/rccm.201712-2553OC. Am J Respir Crit Care Med. 2019. PMID: 30107138 Free PMC article.
A Notch3-Marked Subpopulation of Vascular Smooth Muscle Cells Is the Cell of Origin for Occlusive Pulmonary Vascular Lesions.
Steffes LC, Froistad AA, Andruska A, Boehm M, McGlynn M, Zhang F, Zhang W, Hou D, Tian X, Miquerol L, Nadeau K, Metzger RJ, Spiekerkoetter E, Kumar ME. Steffes LC, et al. Among authors: spiekerkoetter e. Circulation. 2020 Oct 20;142(16):1545-1561. doi: 10.1161/CIRCULATIONAHA.120.045750. Epub 2020 Aug 14. Circulation. 2020. PMID: 32794408 Free PMC article.
67 results