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Targeting Endoglin-Expressing Regulatory T Cells in the Tumor Microenvironment Enhances the Effect of PD1 Checkpoint Inhibitor Immunotherapy.
Schoonderwoerd MJA, Koops MFM, Angela RA, Koolmoes B, Toitou M, Paauwe M, Barnhoorn MC, Liu Y, Sier CFM, Hardwick JCH, Nixon AB, Theuer CP, Fransen MF, Hawinkels LJAC. Schoonderwoerd MJA, et al. Among authors: hardwick jch. Clin Cancer Res. 2020 Jul 15;26(14):3831-3842. doi: 10.1158/1078-0432.CCR-19-2889. Epub 2020 Apr 24. Clin Cancer Res. 2020. PMID: 32332012
The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC.
Voorneveld PW, Kodach LL, Jacobs RJ, van Noesel CJ, Peppelenbosch MP, Korkmaz KS, Molendijk I, Dekker E, Morreau H, van Pelt GW, Tollenaar RA, Mesker W, Hawinkels LJ, Paauwe M, Verspaget HW, Geraets DT, Hommes DW, Offerhaus GJ, van den Brink GR, Ten Dijke P, Hardwick JC. Voorneveld PW, et al. Br J Cancer. 2015 Jan 6;112(1):122-30. doi: 10.1038/bjc.2014.560. Epub 2014 Nov 13. Br J Cancer. 2015. PMID: 25393365 Free PMC article.
Putting the Wnt up colon cancer.
Hawinkels LJ, Hardwick JC. Hawinkels LJ, et al. Gut. 2017 Jun;66(6):983-984. doi: 10.1136/gutjnl-2016-312584. Epub 2016 Nov 10. Gut. 2017. PMID: 28501817 No abstract available.
Endoglin Expression on Cancer-Associated Fibroblasts Regulates Invasion and Stimulates Colorectal Cancer Metastasis.
Paauwe M, Schoonderwoerd MJA, Helderman RFCP, Harryvan TJ, Groenewoud A, van Pelt GW, Bor R, Hemmer DM, Versteeg HH, Snaar-Jagalska BE, Theuer CP, Hardwick JCH, Sier CFM, Ten Dijke P, Hawinkels LJAC. Paauwe M, et al. Among authors: hardwick jch. Clin Cancer Res. 2018 Dec 15;24(24):6331-6344. doi: 10.1158/1078-0432.CCR-18-0329. Epub 2018 Jun 26. Clin Cancer Res. 2018. PMID: 29945992
Bidirectional tumor/stroma crosstalk promotes metastasis in mesenchymal colorectal cancer.
Ouahoud S, Voorneveld PW, van der Burg LRA, de Jonge-Muller ESM, Schoonderwoerd MJA, Paauwe M, de Vos T, de Wit S, van Pelt GW, Mesker WE, Hawinkels LJAC, Hardwick JCH. Ouahoud S, et al. Among authors: hardwick jch. Oncogene. 2020 Mar;39(12):2453-2466. doi: 10.1038/s41388-020-1157-z. Epub 2020 Jan 23. Oncogene. 2020. PMID: 31974473
105 results