Ortega F - Search Results

1

Validation of quantitative measure of repolarization reserve as a novel marker of drug induced proarrhythmia.

Gaur N, Ortega F, Verkerk AO, Mengarelli I, Krogh-Madsen T, Christini DJ, Coronel R, Vigmond EJ. Gaur N, et al. Among authors: ortega f. J Mol Cell Cardiol. 2020 Aug;145:122-132. doi: 10.1016/j.yjmcc.2020.04.019. Epub 2020 Apr 20. J Mol Cell Cardiol. 2020. PMID: 32325153

2

Rapid genetic algorithm optimization of a mouse computational model: benefits for anthropomorphization of neonatal mouse cardiomyocytes.

Bot CT, Kherlopian AR, Ortega FA, Christini DJ, Krogh-Madsen T. Bot CT, et al. Front Physiol. 2012 Nov 5;3:421. doi: 10.3389/fphys.2012.00421. eCollection 2012. Front Physiol. 2012. PMID: 23133423 Free PMC article.

3

Voltage and calcium dynamics both underlie cellular alternans in cardiac myocytes.

Groenendaal W, Ortega FA, Krogh-Madsen T, Christini DJ. Groenendaal W, et al. Biophys J. 2014 May 20;106(10):2222-32. doi: 10.1016/j.bpj.2014.03.048. Biophys J. 2014. PMID: 24853751 Free PMC article.

4

Dynamic clamp in cardiac and neuronal systems using RTXI.

Ortega FA, Butera RJ, Christini DJ, White JA, Dorval AD 2nd. Ortega FA, et al. Methods Mol Biol. 2014;1183:327-54. doi: 10.1007/978-1-4939-1096-0_21. Methods Mol Biol. 2014. PMID: 25023319 Free PMC article.

5

Cell-specific cardiac electrophysiology models.

Groenendaal W, Ortega FA, Kherlopian AR, Zygmunt AC, Krogh-Madsen T, Christini DJ. Groenendaal W, et al. PLoS Comput Biol. 2015 Apr 30;11(4):e1004242. doi: 10.1371/journal.pcbi.1004242. eCollection 2015 Apr. PLoS Comput Biol. 2015. PMID: 25928268 Free PMC article.

6

Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility.

Devenyi RA, Ortega FA, Groenendaal W, Krogh-Madsen T, Christini DJ, Sobie EA. Devenyi RA, et al. J Physiol. 2017 Apr 1;595(7):2301-2317. doi: 10.1113/JP273191. Epub 2016 Dec 28. J Physiol. 2017. PMID: 27779762 Free PMC article.

7

Global Optimization of Ventricular Myocyte Model to Multi-Variable Objective Improves Predictions of Drug-Induced Torsades de Pointes.

Krogh-Madsen T, Jacobson AF, Ortega FA, Christini DJ. Krogh-Madsen T, et al. Among authors: ortega fa. Front Physiol. 2017 Dec 19;8:1059. doi: 10.3389/fphys.2017.01059. eCollection 2017. Front Physiol. 2017. PMID: 29311985 Free PMC article.

8

Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing.

Ortega FA, Grandi E, Krogh-Madsen T, Christini DJ. Ortega FA, et al. Front Physiol. 2018 Jan 4;8:1099. doi: 10.3389/fphys.2017.01099. eCollection 2017. Front Physiol. 2018. PMID: 29354069 Free PMC article. Review.

9

A human embryonic stem cell reporter line for monitoring chemical-induced cardiotoxicity.

Tsai SY, Ghazizadeh Z, Wang HJ, Amin S, Ortega FA, Badieyan ZS, Hsu ZT, Gordillo M, Kumar R, Christini DJ, Evans T, Chen S. Tsai SY, et al. Cardiovasc Res. 2020 Mar 1;116(3):658-670. doi: 10.1093/cvr/cvz148. Cardiovasc Res. 2020. PMID: 31173076 Free PMC article.

10

Overexpression of Map3k7 activates sinoatrial node-like differentiation in mouse ES-derived cardiomyocytes.

Brown K, Legros S, Ortega FA, Dai Y, Doss MX, Christini DJ, Robinson RB, Foley AC. Brown K, et al. PLoS One. 2017 Dec 27;12(12):e0189818. doi: 10.1371/journal.pone.0189818. eCollection 2017. PLoS One. 2017. PMID: 29281682 Free PMC article.

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