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Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical-stage soluble guanylate cyclase stimulator in rats.
Pharmacol Res Perspect. 2020 Apr;8(2):e00579. doi: 10.1002/prp2.579.
Pharmacol Res Perspect. 2020.
PMID: 32314550
Free PMC article.
Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator.
Rennie GR, Barden TC, Bernier SG, Carvalho A, Deming R, Germano P, Hudson C, Im GJ, Iyengar RR, Jia L, Jung J, Kim E, Lee TW, Mermerian A, Moore J, Nakai T, Perl NR, Tobin J, Zimmer DP, Renhowe PA.
Rennie GR, et al. Among authors: barden tc.
Bioorg Med Chem Lett. 2021 May 15;40:127886. doi: 10.1016/j.bmcl.2021.127886. Epub 2021 Mar 2.
Bioorg Med Chem Lett. 2021.
PMID: 33662540
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Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans.
Nakai T, Perl NR, Barden TC, Carvalho A, Fretzen A, Germano P, Im GY, Jin H, Kim C, Lee TW, Long K, Moore J, Rohde JM, Sarno R, Segal C, Solberg EO, Tobin J, Zimmer DP, Currie MG.
Nakai T, et al. Among authors: barden tc.
ACS Med Chem Lett. 2016 Feb 24;7(5):465-9. doi: 10.1021/acsmedchemlett.5b00479. eCollection 2016 May 12.
ACS Med Chem Lett. 2016.
PMID: 27190594
Free PMC article.
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"Glycylcyclines". 3. 9-Aminodoxycyclinecarboxamides.
Barden TC, Buckwalter BL, Testa RT, Petersen PJ, Lee VJ.
Barden TC, et al.
J Med Chem. 1994 Sep 30;37(20):3205-11. doi: 10.1021/jm00046a003.
J Med Chem. 1994.
PMID: 7932547
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