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Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical-stage soluble guanylate cyclase stimulator in rats.
Banijamali AR, Carvalho AE, Wakefield JD, Germano P, Barden TC, Tobin JV, Zimmer DP, Masferrer JL, Profy AT, Currie MG, Todd Milne G. Banijamali AR, et al. Among authors: barden tc. Pharmacol Res Perspect. 2020 Apr;8(2):e00579. doi: 10.1002/prp2.579. Pharmacol Res Perspect. 2020. PMID: 32314550 Free PMC article.
Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator.
Rennie GR, Barden TC, Bernier SG, Carvalho A, Deming R, Germano P, Hudson C, Im GJ, Iyengar RR, Jia L, Jung J, Kim E, Lee TW, Mermerian A, Moore J, Nakai T, Perl NR, Tobin J, Zimmer DP, Renhowe PA. Rennie GR, et al. Among authors: barden tc. Bioorg Med Chem Lett. 2021 May 15;40:127886. doi: 10.1016/j.bmcl.2021.127886. Epub 2021 Mar 2. Bioorg Med Chem Lett. 2021. PMID: 33662540
Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans.
Nakai T, Perl NR, Barden TC, Carvalho A, Fretzen A, Germano P, Im GY, Jin H, Kim C, Lee TW, Long K, Moore J, Rohde JM, Sarno R, Segal C, Solberg EO, Tobin J, Zimmer DP, Currie MG. Nakai T, et al. Among authors: barden tc. ACS Med Chem Lett. 2016 Feb 24;7(5):465-9. doi: 10.1021/acsmedchemlett.5b00479. eCollection 2016 May 12. ACS Med Chem Lett. 2016. PMID: 27190594 Free PMC article.