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The SCFSkp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L).
Roberts JZ, Holohan C, Sessler T, Fox J, Crawford N, Riley JS, Khawaja H, Majkut J, Evergren E, Humphreys LM, Ferris J, Higgins C, Espona-Fiedler M, Moynagh P, McDade SS, Longley DB. Roberts JZ, et al. Among authors: mcdade ss. Cell Death Differ. 2020 Sep;27(9):2726-2741. doi: 10.1038/s41418-020-0539-7. Epub 2020 Apr 20. Cell Death Differ. 2020. PMID: 32313199 Free PMC article.
Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer.
Dunne PD, McArt DG, Bradley CA, O'Reilly PG, Barrett HL, Cummins R, O'Grady T, Arthur K, Loughrey MB, Allen WL, McDade SS, Waugh DJ, Hamilton PW, Longley DB, Kay EW, Johnston PG, Lawler M, Salto-Tellez M, Van Schaeybroeck S. Dunne PD, et al. Among authors: mcdade ss. Clin Cancer Res. 2016 Aug 15;22(16):4095-104. doi: 10.1158/1078-0432.CCR-16-0032. Epub 2016 May 5. Clin Cancer Res. 2016. PMID: 27151745
Immune-Derived PD-L1 Gene Expression Defines a Subgroup of Stage II/III Colorectal Cancer Patients with Favorable Prognosis Who May Be Harmed by Adjuvant Chemotherapy.
Dunne PD, McArt DG, O'Reilly PG, Coleman HG, Allen WL, Loughrey M, Van Schaeybroeck S, McDade S, Salto-Tellez M, Longley DB, Lawler M, Johnston PG. Dunne PD, et al. Cancer Immunol Res. 2016 Jul;4(7):582-91. doi: 10.1158/2326-6066.CIR-15-0302. Epub 2016 May 13. Cancer Immunol Res. 2016. PMID: 27197062
The pseudo-caspase FLIP(L) regulates cell fate following p53 activation.
Lees A, McIntyre AJ, Crawford NT, Falcone F, McCann C, Holohan C, Quinn GP, Roberts JZ, Sessler T, Gallagher PF, Gregg GMA, McAllister K, McLaughlin KM, Allen WL, Egan LJ, Ryan AE, Labonte-Wilson MJ, Dunne PD, Wappett M, Coyle VM, Johnston PG, Kerr EM, Longley DB, McDade SS. Lees A, et al. Among authors: mcdade ss. Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):17808-17819. doi: 10.1073/pnas.2001520117. Epub 2020 Jul 13. Proc Natl Acad Sci U S A. 2020. PMID: 32661168 Free PMC article.
Dying to Survive-The p53 Paradox.
Lees A, Sessler T, McDade S. Lees A, et al. Cancers (Basel). 2021 Jun 29;13(13):3257. doi: 10.3390/cancers13133257. Cancers (Basel). 2021. PMID: 34209840 Free PMC article. Review.
60 results