Nencka R - Search Results

1

Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer's Disease.

Šála M, Hollinger KR, Thomas AG, Dash RP, Tallon C, Veeravalli V, Lovell L, Kögler M, Hřebabecký H, Procházková E, Nešuta O, Donoghue A, Lam J, Rais R, Rojas C, Slusher BS, Nencka R. Šála M, et al. Among authors: nencka r. J Med Chem. 2020 Jun 11;63(11):6028-6056. doi: 10.1021/acs.jmedchem.0c00278. Epub 2020 May 27. J Med Chem. 2020. PMID: 32298582 Free PMC article.

2

Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase.

Nencka R, Votruba I, Hrebabecký H, Tloust'ová E, Horská K, Masojídková M, Holý A. Nencka R, et al. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1335-7. doi: 10.1016/j.bmcl.2005.11.050. Epub 2005 Dec 5. Bioorg Med Chem Lett. 2006. PMID: 16337119

3

Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase.

Nencka R, Votruba I, Hrebabecký H, Jansa P, Tloust'ová E, Horská K, Masojídková M, Holý A. Nencka R, et al. J Med Chem. 2007 Nov 29;50(24):6016-23. doi: 10.1021/jm070644i. Epub 2007 Oct 27. J Med Chem. 2007. PMID: 17963370

4

Design, synthesis, and biological evaluation of novel coxsackievirus B3 inhibitors.

Sála M, De Palma AM, Hrebabecký H, Nencka R, Dracínský M, Leyssen P, Neyts J, Holý A. Sála M, et al. Among authors: nencka r. Bioorg Med Chem. 2010 Jun 15;18(12):4374-84. doi: 10.1016/j.bmc.2010.04.081. Epub 2010 Apr 29. Bioorg Med Chem. 2010. PMID: 20576576

5

SAR studies of 9-norbornylpurines as Coxsackievirus B3 inhibitors.

Sála M, De Palma AM, Hřebabecký H, Dejmek M, Dračínský M, Leyssen P, Neyts J, Mertlíková-Kaiserová H, Nencka R. Sála M, et al. Among authors: nencka r. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4271-5. doi: 10.1016/j.bmcl.2011.05.070. Epub 2011 May 27. Bioorg Med Chem Lett. 2011. PMID: 21684160

6

Novel substituted 9-norbornylpurines and their activities against RNA viruses.

Sála M, Hřebabecký H, Leyssen P, Dejmek M, Dračínský M, De Palma AM, Neyts J, Nencka R. Sála M, et al. Among authors: nencka r. Bioorg Med Chem Lett. 2012 Mar 1;22(5):1963-8. doi: 10.1016/j.bmcl.2012.01.040. Epub 2012 Jan 25. Bioorg Med Chem Lett. 2012. PMID: 22310228

7

C6-substituted purine derivatives: an experimental and theoretical 1H, 13C and 15N NMR study.

Procházková E, Sála M, Nencka R, Dračínský M. Procházková E, et al. Among authors: nencka r. Magn Reson Chem. 2012 Mar;50(3):181-6. doi: 10.1002/mrc.2864. Epub 2012 Feb 26. Magn Reson Chem. 2012. PMID: 22367771

8

9-Norbornyl-6-chloropurine is a novel antileukemic compound interacting with cellular GSH.

Placková P, Rozumová N, Hrebabecky H, Sála M, Nencka R, Elbert T, Dvoráková A, Votruba I, Mertlíková-Kaiserová H. Placková P, et al. Among authors: nencka r. Anticancer Res. 2013 Aug;33(8):3163-8. Anticancer Res. 2013. PMID: 23898074

9

Synthesis of novel purine-based coxsackievirus inhibitors bearing polycylic substituents at the N-9 position.

Dejmek M, Sála M, Plačková P, Hřebabecký H, Mascarell Borredà L, Neyts J, Dračínský M, Procházková E, Jansa P, Leyssen P, Mertlíková-Kaiserová H, Nencka R. Dejmek M, et al. Among authors: nencka r. Arch Pharm (Weinheim). 2014 Jul;347(7):478-85. doi: 10.1002/ardp.201300431. Epub 2014 Mar 20. Arch Pharm (Weinheim). 2014. PMID: 24652670

10

Transport mechanisms of a novel antileukemic and antiviral compound 9-norbornyl-6-chloropurine.

Plačková P, Hřebabecký H, Šála M, Nencka R, Elbert T, Mertlíková-Kaiserová H. Plačková P, et al. Among authors: nencka r. J Enzyme Inhib Med Chem. 2015 Feb;30(1):57-62. doi: 10.3109/14756366.2013.879576. Epub 2014 Mar 31. J Enzyme Inhib Med Chem. 2015. PMID: 24679051

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