Wegmann S - Search Results

1

LRP1 is a master regulator of tau uptake and spread.

Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, Leshuk C, Hernandez I, Wegmann S, Hyman BT, Gradinaru V, Kampmann M, Kosik KS. Rauch JN, et al. Among authors: wegmann s. Nature. 2020 Apr;580(7803):381-385. doi: 10.1038/s41586-020-2156-5. Epub 2020 Apr 1. Nature. 2020. PMID: 32296178 Free PMC article.

2

Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology.

Pooler AM, Polydoro M, Wegmann SK, Pitstick R, Kay KR, Sanchez L, Carlson GA, Gomez-Isla T, Albers MW, Spires-Jones TL, Hyman BT. Pooler AM, et al. J Comp Neurol. 2013 Dec 15;521(18):4236-48. doi: 10.1002/cne.23411. J Comp Neurol. 2013. PMID: 23839581 Free PMC article.

3

Propagation of tau pathology in Alzheimer's disease: identification of novel therapeutic targets.

Pooler AM, Polydoro M, Wegmann S, Nicholls SB, Spires-Jones TL, Hyman BT. Pooler AM, et al. Among authors: wegmann s. Alzheimers Res Ther. 2013 Oct 23;5(5):49. doi: 10.1186/alzrt214. eCollection 2013. Alzheimers Res Ther. 2013. PMID: 24152385 Free PMC article. Review.

4

Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy.

Kopeikina KJ, Wegmann S, Pitstick R, Carlson GA, Bacskai BJ, Betensky RA, Hyman BT, Spires-Jones TL. Kopeikina KJ, et al. Among authors: wegmann s. PLoS One. 2013 Nov 20;8(11):e80834. doi: 10.1371/journal.pone.0080834. eCollection 2013. PLoS One. 2013. PMID: 24278327 Free PMC article.

5

Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo.

Kuchibhotla KV, Wegmann S, Kopeikina KJ, Hawkes J, Rudinskiy N, Andermann ML, Spires-Jones TL, Bacskai BJ, Hyman BT. Kuchibhotla KV, et al. Among authors: wegmann s. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):510-4. doi: 10.1073/pnas.1318807111. Epub 2013 Dec 24. Proc Natl Acad Sci U S A. 2014. PMID: 24368848 Free PMC article.

6

Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses.

Rudinskiy N, Hawkes JM, Wegmann S, Kuchibhotla KV, Muzikansky A, Betensky RA, Spires-Jones TL, Hyman BT. Rudinskiy N, et al. Among authors: wegmann s. Acta Neuropathol Commun. 2014 Jun 10;2:63. doi: 10.1186/2051-5960-2-63. Acta Neuropathol Commun. 2014. PMID: 24915991 Free PMC article.

7

A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer disease.

Hori Y, Takeda S, Cho H, Wegmann S, Shoup TM, Takahashi K, Irimia D, Elmaleh DR, Hyman BT, Hudry E. Hori Y, et al. Among authors: wegmann s. J Biol Chem. 2015 Jan 23;290(4):1966-78. doi: 10.1074/jbc.M114.586602. Epub 2014 Dec 2. J Biol Chem. 2015. PMID: 25468905 Free PMC article.

8

Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease.

Pooler AM, Polydoro M, Maury EA, Nicholls SB, Reddy SM, Wegmann S, William C, Saqran L, Cagsal-Getkin O, Pitstick R, Beier DR, Carlson GA, Spires-Jones TL, Hyman BT. Pooler AM, et al. Among authors: wegmann s. Acta Neuropathol Commun. 2015 Mar 24;3:14. doi: 10.1186/s40478-015-0199-x. Acta Neuropathol Commun. 2015. PMID: 25853174 Free PMC article.

9

Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.

Takeda S, Wegmann S, Cho H, DeVos SL, Commins C, Roe AD, Nicholls SB, Carlson GA, Pitstick R, Nobuhara CK, Costantino I, Frosch MP, Müller DJ, Irimia D, Hyman BT. Takeda S, et al. Among authors: wegmann s. Nat Commun. 2015 Oct 13;6:8490. doi: 10.1038/ncomms9490. Nat Commun. 2015. PMID: 26458742 Free PMC article.

10

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity.

Wegmann S, Maury EA, Kirk MJ, Saqran L, Roe A, DeVos SL, Nicholls S, Fan Z, Takeda S, Cagsal-Getkin O, William CM, Spires-Jones TL, Pitstick R, Carlson GA, Pooler AM, Hyman BT. Wegmann S, et al. EMBO J. 2015 Dec 14;34(24):3028-41. doi: 10.15252/embj.201592748. Epub 2015 Nov 4. EMBO J. 2015. PMID: 26538322 Free PMC article.

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