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LRP1 is a master regulator of tau uptake and spread.
Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, Leshuk C, Hernandez I, Wegmann S, Hyman BT, Gradinaru V, Kampmann M, Kosik KS. Rauch JN, et al. Among authors: hyman bt. Nature. 2020 Apr;580(7803):381-385. doi: 10.1038/s41586-020-2156-5. Epub 2020 Apr 1. Nature. 2020. PMID: 32296178 Free PMC article.
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
Schlossmacher MG, Frosch MP, Gai WP, Medina M, Sharma N, Forno L, Ochiishi T, Shimura H, Sharon R, Hattori N, Langston JW, Mizuno Y, Hyman BT, Selkoe DJ, Kosik KS. Schlossmacher MG, et al. Among authors: hyman bt. Am J Pathol. 2002 May;160(5):1655-67. doi: 10.1016/S0002-9440(10)61113-3. Am J Pathol. 2002. PMID: 12000718 Free PMC article.
Tau pathophysiology in neurodegeneration: a tangled issue.
Spires-Jones TL, Stoothoff WH, de Calignon A, Jones PB, Hyman BT. Spires-Jones TL, et al. Among authors: hyman bt. Trends Neurosci. 2009 Mar;32(3):150-9. doi: 10.1016/j.tins.2008.11.007. Epub 2009 Jan 21. Trends Neurosci. 2009. PMID: 19162340 Review.
Caspase activation precedes and leads to tangles.
de Calignon A, Fox LM, Pitstick R, Carlson GA, Bacskai BJ, Spires-Jones TL, Hyman BT. de Calignon A, et al. Among authors: hyman bt. Nature. 2010 Apr 22;464(7292):1201-4. doi: 10.1038/nature08890. Epub 2010 Mar 31. Nature. 2010. PMID: 20357768 Free PMC article.
Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology.
Pooler AM, Polydoro M, Wegmann SK, Pitstick R, Kay KR, Sanchez L, Carlson GA, Gomez-Isla T, Albers MW, Spires-Jones TL, Hyman BT. Pooler AM, et al. Among authors: hyman bt. J Comp Neurol. 2013 Dec 15;521(18):4236-48. doi: 10.1002/cne.23411. J Comp Neurol. 2013. PMID: 23839581 Free PMC article.
833 results