Wang Z - Search Results

1

Discovery of [1,2,4]Triazolo[1,5-a]pyridine Derivatives as Potent and Orally Bioavailable RORγt Inverse Agonists.

Nakajima R, Oono H, Sugiyama S, Matsueda Y, Ida T, Kakuda S, Hirata J, Baba A, Makino A, Matsuyama R, White RD, Wurz RΡ, Shin Y, Min X, Guzman-Perez A, Wang Z, Symons A, Singh SK, Mothe SR, Belyakov S, Chakrabarti A, Shuto S. Nakajima R, et al. Among authors: wang z. ACS Med Chem Lett. 2020 Feb 27;11(4):528-534. doi: 10.1021/acsmedchemlett.9b00649. eCollection 2020 Apr 9. ACS Med Chem Lett. 2020. PMID: 32292560 Free PMC article.

2

Discovery of 6-Oxo-4-phenyl-hexanoic acid derivatives as RORγt inverse agonists showing favorable ADME profile.

Nakajima R, Oono H, Kumazawa K, Ida T, Hirata J, White RD, Min X, Guzman-Perez A, Wang Z, Symons A, Singh SK, Mothe SR, Belyakov S, Chakrabarti A, Shuto S. Nakajima R, et al. Among authors: wang z. Bioorg Med Chem Lett. 2021 Mar 15;36:127786. doi: 10.1016/j.bmcl.2021.127786. Epub 2021 Jan 23. Bioorg Med Chem Lett. 2021. PMID: 33493627

3

Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction.

Chen X, Kopecky DJ, Mihalic J, Jeffries S, Min X, Heath J, Deignan J, Lai S, Fu Z, Guimaraes C, Shen S, Li S, Johnstone S, Thibault S, Xu H, Cardozo M, Shen W, Walker N, Kayser F, Wang Z. Chen X, et al. Among authors: wang z. J Med Chem. 2012 Apr 26;55(8):3837-51. doi: 10.1021/jm300037x. Epub 2012 Apr 18. J Med Chem. 2012. PMID: 22458568

4

Discovery of Tarantula Venom-Derived Na_V1.7-Inhibitory JzTx-V Peptide 5-Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis.

Wu B, Murray JK, Andrews KL, Sham K, Long J, Aral J, Ligutti J, Amagasu S, Liu D, Zou A, Min X, Wang Z, Ilch CP, Kornecook TJ, Lin MJ, Be X, Miranda LP, Moyer BD, Biswas K. Wu B, et al. Among authors: wang z. J Med Chem. 2018 Nov 8;61(21):9500-9512. doi: 10.1021/acs.jmedchem.8b00736. Epub 2018 Oct 22. J Med Chem. 2018. PMID: 30346167

5

Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors.

Gustin DJ, Ma Z, Min X, Li Y, Hedberg C, Guimaraes C, Porter AC, Lindstrom M, Lester-Zeiner D, Xu G, Carlson TJ, Xiao S, Meleza C, Connors R, Wang Z, Kayser F. Gustin DJ, et al. Among authors: wang z. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2492-6. doi: 10.1016/j.bmcl.2011.02.052. Epub 2011 Feb 17. Bioorg Med Chem Lett. 2011. PMID: 21392988

6

Crystal structure of a single-chain trimer of human adiponectin globular domain.

Min X, Lemon B, Tang J, Liu Q, Zhang R, Walker N, Li Y, Wang Z. Min X, et al. Among authors: wang z. FEBS Lett. 2012 Mar 23;586(6):912-7. doi: 10.1016/j.febslet.2012.02.024. Epub 2012 Feb 22. FEBS Lett. 2012. PMID: 22449980 Free article.

7

Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions.

Min X, Weiszmann J, Johnstone S, Wang W, Yu X, Romanow W, Thibault S, Li Y, Wang Z. Min X, et al. Among authors: wang w, wang z. J Biol Chem. 2018 Sep 21;293(38):14678-14688. doi: 10.1074/jbc.RA118.004343. Epub 2018 Aug 1. J Biol Chem. 2018. PMID: 30068552 Free PMC article.

8

Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH).

Min X, Thibault ST, Porter AC, Gustin DJ, Carlson TJ, Xu H, Lindstrom M, Xu G, Uyeda C, Ma Z, Li Y, Kayser F, Walker NP, Wang Z. Min X, et al. Among authors: wang z. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7379-84. doi: 10.1073/pnas.1016167108. Epub 2011 Apr 18. Proc Natl Acad Sci U S A. 2011. PMID: 21502526 Free PMC article.

9

Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor.

Hale C, Véniant M, Wang Z, Chen M, McCormick J, Cupples R, Hickman D, Min X, Sudom A, Xu H, Matsumoto G, Fotsch C, St Jean DJ Jr, Wang M. Hale C, et al. Among authors: wang z, wang m. Chem Biol Drug Des. 2008 Jan;71(1):36-44. doi: 10.1111/j.1747-0285.2007.00603.x. Epub 2007 Dec 7. Chem Biol Drug Des. 2008. PMID: 18069989

10

Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies.

Zhang H, Huang CS, Yu X, Lee J, Vaish A, Chen Q, Zhou M, Wang Z, Min X. Zhang H, et al. Among authors: wang z. Commun Biol. 2021 May 5;4(1):526. doi: 10.1038/s42003-021-02039-8. Commun Biol. 2021. PMID: 33953337 Free PMC article.

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