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Metabolic Fingerprinting with Fourier-Transform Infrared (FTIR) Spectroscopy: Towards a High-Throughput Screening Assay for Antibiotic Discovery and Mechanism-of-Action Elucidation.
Metabolites. 2020 Apr 9;10(4):145. doi: 10.3390/metabo10040145.
Metabolites. 2020.
PMID: 32283661
Free PMC article.
A phenotypic screening bioassay for Escherichia coli stress and antibiotic responses based on Fourier-transform infrared (FTIR) spectroscopy and multivariate analysis.
Ribeiro da Cunha B, Fonseca LP, Calado CRC.
Ribeiro da Cunha B, et al.
J Appl Microbiol. 2019 Dec;127(6):1776-1789. doi: 10.1111/jam.14429. Epub 2019 Oct 8.
J Appl Microbiol. 2019.
PMID: 31464358
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Simultaneous elucidation of antibiotic mechanism of action and potency with high-throughput Fourier-transform infrared (FTIR) spectroscopy and machine learning.
Ribeiro da Cunha B, Fonseca LP, Calado CRC.
Ribeiro da Cunha B, et al.
Appl Microbiol Biotechnol. 2021 Feb;105(3):1269-1286. doi: 10.1007/s00253-021-11102-7. Epub 2021 Jan 14.
Appl Microbiol Biotechnol. 2021.
PMID: 33443637
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Antibiotic Discovery: Where Have We Come from, Where Do We Go?
Ribeiro da Cunha B, Fonseca LP, Calado CRC.
Ribeiro da Cunha B, et al.
Antibiotics (Basel). 2019 Apr 24;8(2):45. doi: 10.3390/antibiotics8020045.
Antibiotics (Basel). 2019.
PMID: 31022923
Free PMC article.
Review.
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Fast identification of off-target liabilities in early antibiotic discovery with Fourier-transform infrared spectroscopy.
Ribeiro da Cunha B, Aleixo SM, Fonseca LP, Calado CRC.
Ribeiro da Cunha B, et al.
Biotechnol Bioeng. 2021 Nov;118(11):4465-4476. doi: 10.1002/bit.27915. Epub 2021 Aug 20.
Biotechnol Bioeng. 2021.
PMID: 34396508
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