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Defective proteasome biogenesis into skin fibroblasts isolated from Rett syndrome subjects with MeCP2 non-sense mutations.
Sbardella D, Tundo GR, Cunsolo V, Grasso G, Cascella R, Caputo V, Santoro AM, Milardi D, Pecorelli A, Ciaccio C, Di Pierro D, Leoncini S, Campagnolo L, Pironi V, Oddone F, Manni P, Foti S, Giardina E, De Felice C, Hayek J, Curatolo P, Galasso C, Valacchi G, Coletta M, Graziani G, Marini S. Sbardella D, et al. Among authors: grasso g. Biochim Biophys Acta Mol Basis Dis. 2020 Jul 1;1866(7):165793. doi: 10.1016/j.bbadis.2020.165793. Epub 2020 Apr 8. Biochim Biophys Acta Mol Basis Dis. 2020. PMID: 32275946 Free article.
Metal ions affect insulin-degrading enzyme activity.
Grasso G, Salomone F, Tundo GR, Pappalardo G, Ciaccio C, Spoto G, Pietropaolo A, Coletta M, Rizzarelli E. Grasso G, et al. J Inorg Biochem. 2012 Dec;117:351-8. doi: 10.1016/j.jinorgbio.2012.06.010. Epub 2012 Jun 23. J Inorg Biochem. 2012. PMID: 22819648
Multiple functions of insulin-degrading enzyme: a metabolic crosslight?
Tundo GR, Sbardella D, Ciaccio C, Grasso G, Gioia M, Coletta A, Polticelli F, Di Pierro D, Milardi D, Van Endert P, Marini S, Coletta M. Tundo GR, et al. Among authors: grasso g. Crit Rev Biochem Mol Biol. 2017 Oct;52(5):554-582. doi: 10.1080/10409238.2017.1337707. Epub 2017 Jun 21. Crit Rev Biochem Mol Biol. 2017. PMID: 28635330 Review.
The insulin-degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S.
Sbardella D, Tundo GR, Coletta A, Marcoux J, Koufogeorgou EI, Ciaccio C, Santoro AM, Milardi D, Grasso G, Cozza P, Bousquet-Dubouch MP, Marini S, Coletta M. Sbardella D, et al. Among authors: grasso g. Cell Mol Life Sci. 2018 Sep;75(18):3441-3456. doi: 10.1007/s00018-018-2807-y. Epub 2018 Mar 28. Cell Mol Life Sci. 2018. PMID: 29594388 Free PMC article.
Ubiquitin binds the amyloid β peptide and interferes with its clearance pathways.
Bellia F, Lanza V, García-Viñuales S, Ahmed IMM, Pietropaolo A, Iacobucci C, Malgieri G, D'Abrosca G, Fattorusso R, Nicoletti VG, Sbardella D, Tundo GR, Coletta M, Pirone L, Pedone E, Calcagno D, Grasso G, Milardi D. Bellia F, et al. Among authors: grasso g. Chem Sci. 2019 Jan 10;10(9):2732-2742. doi: 10.1039/c8sc03394c. eCollection 2019 Mar 7. Chem Sci. 2019. PMID: 30996991 Free PMC article.
661 results