Gilbert IH - Search Results

1

Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase.

Torrie LS, Robinson DA, Thomas MG, Hobrath JV, Shepherd SM, Post JM, Ko EJ, Ferreira RA, Mackenzie CJ, Wrobel K, Edwards DP, Gilbert IH, Gray DW, Fairlamb AH, De Rycker M. Torrie LS, et al. Among authors: gilbert ih. ACS Infect Dis. 2020 May 8;6(5):1044-1057. doi: 10.1021/acsinfecdis.9b00453. Epub 2020 Apr 28. ACS Infect Dis. 2020. PMID: 32275825 Free PMC article.

2

Target assessment for antiparasitic drug discovery.

Frearson JA, Wyatt PG, Gilbert IH, Fairlamb AH. Frearson JA, et al. Among authors: gilbert ih. Trends Parasitol. 2007 Dec;23(12):589-95. doi: 10.1016/j.pt.2007.08.019. Epub 2007 Oct 24. Trends Parasitol. 2007. PMID: 17962072 Free PMC article. Review.

3

One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening.

Mpamhanga CP, Spinks D, Tulloch LB, Shanks EJ, Robinson DA, Collie IT, Fairlamb AH, Wyatt PG, Frearson JA, Hunter WN, Gilbert IH, Brenk R. Mpamhanga CP, et al. Among authors: gilbert ih. J Med Chem. 2009 Jul 23;52(14):4454-65. doi: 10.1021/jm900414x. J Med Chem. 2009. PMID: 19527033 Free PMC article.

4

Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis.

Richardson JL, Nett IR, Jones DC, Abdille MH, Gilbert IH, Fairlamb AH. Richardson JL, et al. Among authors: gilbert ih. ChemMedChem. 2009 Aug;4(8):1333-40. doi: 10.1002/cmdc.200900097. ChemMedChem. 2009. PMID: 19557801 Free PMC article.

5

Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase.

Patterson S, Jones DC, Shanks EJ, Frearson JA, Gilbert IH, Wyatt PG, Fairlamb AH. Patterson S, et al. Among authors: gilbert ih. ChemMedChem. 2009 Aug;4(8):1341-53. doi: 10.1002/cmdc.200900098. ChemMedChem. 2009. PMID: 19557802 Free PMC article.

6

Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis.

Torrie LS, Wyllie S, Spinks D, Oza SL, Thompson S, Harrison JR, Gilbert IH, Wyatt PG, Fairlamb AH, Frearson JA. Torrie LS, et al. Among authors: gilbert ih. J Biol Chem. 2009 Dec 25;284(52):36137-36145. doi: 10.1074/jbc.M109.045336. Epub 2009 Oct 14. J Biol Chem. 2009. PMID: 19828449 Free PMC article.

7

Investigation of trypanothione reductase as a drug target in Trypanosoma brucei.

Spinks D, Shanks EJ, Cleghorn LA, McElroy S, Jones D, James D, Fairlamb AH, Frearson JA, Wyatt PG, Gilbert IH. Spinks D, et al. Among authors: gilbert ih. ChemMedChem. 2009 Dec;4(12):2060-9. doi: 10.1002/cmdc.200900262. ChemMedChem. 2009. PMID: 19924760 Free PMC article.

8

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.

Frearson JA, Brand S, McElroy SP, Cleghorn LA, Smid O, Stojanovski L, Price HP, Guther ML, Torrie LS, Robinson DA, Hallyburton I, Mpamhanga CP, Brannigan JA, Wilkinson AJ, Hodgkinson M, Hui R, Qiu W, Raimi OG, van Aalten DM, Brenk R, Gilbert IH, Read KD, Fairlamb AH, Ferguson MA, Smith DF, Wyatt PG. Frearson JA, et al. Among authors: gilbert ih. Nature. 2010 Apr 1;464(7289):728-32. doi: 10.1038/nature08893. Nature. 2010. PMID: 20360736 Free PMC article.

9

Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.

Spinks D, Ong HB, Mpamhanga CP, Shanks EJ, Robinson DA, Collie IT, Read KD, Frearson JA, Wyatt PG, Brenk R, Fairlamb AH, Gilbert IH. Spinks D, et al. Among authors: gilbert ih. ChemMedChem. 2011 Feb 7;6(2):302-8. doi: 10.1002/cmdc.201000450. Epub 2010 Dec 29. ChemMedChem. 2011. PMID: 21275054 Free PMC article.

10

Target validation: linking target and chemical properties to desired product profile.

Wyatt PG, Gilbert IH, Read KD, Fairlamb AH. Wyatt PG, et al. Among authors: gilbert ih. Curr Top Med Chem. 2011;11(10):1275-83. doi: 10.2174/156802611795429185. Curr Top Med Chem. 2011. PMID: 21401506 Free PMC article. Review.

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