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Potent lipoprotein(a) lowering following apolipoprotein(a) antisense treatment reduces the pro-inflammatory activation of circulating monocytes in patients with elevated lipoprotein(a).
Stiekema LCA, Prange KHM, Hoogeveen RM, Verweij SL, Kroon J, Schnitzler JG, Dzobo KE, Cupido AJ, Tsimikas S, Stroes ESG, de Winther MPJ, Bahjat M. Stiekema LCA, et al. Among authors: dzobo ke. Eur Heart J. 2020 Jun 21;41(24):2262-2271. doi: 10.1093/eurheartj/ehaa171. Eur Heart J. 2020. PMID: 32268367 Free PMC article.
Lipoprotein(a): An underestimated inflammatory mastermind.
Dzobo KE, Kraaijenhof JM, Stroes ESG, Nurmohamed NS, Kroon J. Dzobo KE, et al. Atherosclerosis. 2022 May;349:101-109. doi: 10.1016/j.atherosclerosis.2022.04.004. Atherosclerosis. 2022. PMID: 35606070 Free article. Review.
Elevated Lp(a) (Lipoprotein[a]) Levels Increase Risk of 30-Day Major Adverse Cardiovascular Events in Patients Following Carotid Endarterectomy.
Waissi F, Dekker M, Timmerman N, Hoogeveen RM, van Bennekom J, Dzobo KE, Schnitzler JG, Pasterkamp G, Grobbee DE, de Borst GJ, Stroes ESG, de Kleijn DPV, Kroon J. Waissi F, et al. Among authors: dzobo ke. Stroke. 2020 Oct;51(10):2972-2982. doi: 10.1161/STROKEAHA.120.030616. Epub 2020 Sep 3. Stroke. 2020. PMID: 32878565 Free article.
BET protein inhibitor apabetalone (RVX-208) suppresses pro-inflammatory hyper-activation of monocytes from patients with cardiovascular disease and type 2 diabetes.
Wasiak S, Dzobo KE, Rakai BD, Kaiser Y, Versloot M, Bahjat M, Stotz SC, Fu L, Sweeney M, Johansson JO, Wong NCW, Stroes ESG, Kroon J, Kulikowski E. Wasiak S, et al. Among authors: dzobo ke. Clin Epigenetics. 2020 Nov 11;12(1):166. doi: 10.1186/s13148-020-00943-0. Clin Epigenetics. 2020. PMID: 33172487 Free PMC article.
Targeting epigenetics as atherosclerosis treatment: an updated view.
Neele AE, Willemsen L, Chen HJ, Dzobo KE, de Winther MPJ. Neele AE, et al. Among authors: dzobo ke. Curr Opin Lipidol. 2020 Dec;31(6):324-330. doi: 10.1097/MOL.0000000000000711. Curr Opin Lipidol. 2020. PMID: 33027226 Free PMC article. Review.
Diacylglycerols and Lysophosphatidic Acid, Enriched on Lipoprotein(a), Contribute to Monocyte Inflammation.
Dzobo KE, Cupido AJ, Mol BM, Stiekema LCA, Versloot M, Winkelmeijer M, Peter J, Pennekamp AM, Havik SR, Vaz FM, van Weeghel M, Prange KHM, Levels JHM, de Winther MPJ, Tsimikas S, Groen AK, Stroes ESG, de Kleijn DPV, Kroon J. Dzobo KE, et al. Arterioscler Thromb Vasc Biol. 2024 Mar;44(3):720-740. doi: 10.1161/ATVBAHA.123.319937. Epub 2024 Jan 25. Arterioscler Thromb Vasc Biol. 2024. PMID: 38269588 Free PMC article.