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Ruthenium(II)/Benzonitrile Complex Induces Cytotoxic Effect in Sarcoma-180 Cells by Caspase-Mediated and Tp53/p21-Mediated Apoptosis, with Moderate Brine Shrimp Toxicity.
Faria RS, Silva HD, Mello-Andrade F, Pires WC, de Castro Pereira F, de Lima AP, de Fátima Oliveira Santos S, Teixeira TM, da Silva PFF, Naves PLF, Batista AA, da Silva Oliveira RJ, Reis RM, de Paula Silveira-Lacerda E. Faria RS, et al. Among authors: pires wc. Biol Trace Elem Res. 2020 Dec;198(2):669-680. doi: 10.1007/s12011-020-02098-8. Epub 2020 Apr 8. Biol Trace Elem Res. 2020. PMID: 32266641
Ru(II)-Based Amino Acid Complexes Show Promise for Leukemia Treatment: Cytotoxicity and Some Light on their Mechanism of Action.
de Lima AP, Almeida MAP, Mello-Andrade F, de Castro Pereira F, Pires WC, Abreu DC, de Souza Velozo-Sá V, Batista AA, de Paula Silveira-Lacerda E. de Lima AP, et al. Among authors: pires wc. Biol Trace Elem Res. 2020 Sep;197(1):123-131. doi: 10.1007/s12011-019-01976-0. Epub 2019 Nov 26. Biol Trace Elem Res. 2020. PMID: 31773484
cis-[RuCl(BzCN)(bipy)(dppe)]PF6 induces anti-angiogenesis and apoptosis by a mechanism of caspase-dependent involving DNA damage, PARP activation, and Tp53 induction in Ehrlich tumor cells.
Magalhães LF, Mello-Andrade F, Pires WC, Silva HD, da Silva PFF, Macedo LM, Henrique de Castro C, Carneiro CC, Cardoso CG, de Melo Reis PR, Camargo de Oliveira L, Caetano RR, Batista AA, Silveira-Lacerda EP. Magalhães LF, et al. Among authors: pires wc. Chem Biol Interact. 2017 Dec 25;278:101-113. doi: 10.1016/j.cbi.2017.09.013. Epub 2017 Sep 19. Chem Biol Interact. 2017. PMID: 28935426
Cis-[RuCl(BzCN)(N-N)(P-P)]PF6 complexes: Synthesis and in vitro antitumor activity: (BzCN=benzonitrile; N-N=2,2'-bipyridine; 1,10-phenanthroline; P-P=1,4-bis(diphenylphosphino) butane, 1,2-bis(diphenylphosphino)ethane, or 1,1'-(diphenylphosphino)ferrocene).
Pereira Fde C, Lima BA, de Lima AP, Pires WC, Monteiro T, Magalhães LF, Costa W, Graminha AE, Batista AA, Ellena J, Siveira-Lacerda Ede P. Pereira Fde C, et al. Among authors: pires wc. J Inorg Biochem. 2015 Aug;149:91-101. doi: 10.1016/j.jinorgbio.2015.03.011. Epub 2015 Mar 31. J Inorg Biochem. 2015. PMID: 25873134
In vitro cytotoxicity and in vivo zebrafish toxicity evaluation of Ru(ii)/2-mercaptopyrimidine complexes.
Velozo-Sá VS , Pereira LR , Lima AP , Mello-Andrade F , Rezende MRM , Goveia RM , Pires WC , Silva MM , Oliveira KM , Ferreira AG , Ellena J , Deflon VM , Grisolia CK , Batista AA , Silveira-Lacerda EP . Velozo-Sá VS , et al. Among authors: pires wc. Dalton Trans. 2019 May 7;48(18):6026-6039. doi: 10.1039/c8dt03738h. Dalton Trans. 2019. PMID: 30724926
Heterobimetallic Ru(ii)/Fe(ii) complexes as potent anticancer agents against breast cancer cells, inducing apoptosis through multiple targets.
Guedes APM , Mello-Andrade F , Pires WC , de Sousa MAM , da Silva PFF , de Camargo MS , Gemeiner H , Amauri MA , Gomes Cardoso C , de Melo Reis PR , Silveira-Lacerda EP , Batista AA . Guedes APM , et al. Among authors: pires wc. Metallomics. 2020 Apr 1;12(4):547-561. doi: 10.1039/c9mt00272c. Epub 2020 Feb 28. Metallomics. 2020. PMID: 32108850
Ru(II)/diphenylphosphine/pyridine-6-thiolate complexes induce S-180 cell apoptosis through intrinsic mitochondrial pathway involving inhibition of Bcl-2 and p53/Bax activation.
Pires WC, Lima BAV, de Castro Pereira F, Lima AP, Mello-Andrade F, Silva HD, da Silva MM, Colina-Vegas L, Ellena J, Batista AA, de Paul Silveira-Lacerda E. Pires WC, et al. Mol Cell Biochem. 2018 Jan;438(1-2):199-217. doi: 10.1007/s11010-017-3129-3. Epub 2017 Aug 9. Mol Cell Biochem. 2018. PMID: 28795366
Ru(II)/amino acid complexes inhibit the progression of breast cancer cells through multiple mechanism-induced apoptosis.
Mello-Andrade F, Guedes APM, Pires WC, Velozo-Sá VS, Delmond KA, Mendes D, Molina MS, Matuda L, de Sousa MAM, Melo-Reis P, Gomes CC, Castro CH, Almeida MAP, Menck CFM, Batista AA, Burikhanov R, Rangnekar VM, Silveira-Lacerda E. Mello-Andrade F, et al. Among authors: pires wc. J Inorg Biochem. 2022 Jan;226:111625. doi: 10.1016/j.jinorgbio.2021.111625. Epub 2021 Oct 7. J Inorg Biochem. 2022. PMID: 34655962
17 results