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Ruthenium(II)/Benzonitrile Complex Induces Cytotoxic Effect in Sarcoma-180 Cells by Caspase-Mediated and Tp53/p21-Mediated Apoptosis, with Moderate Brine Shrimp Toxicity.
Faria RS, Silva HD, Mello-Andrade F, Pires WC, de Castro Pereira F, de Lima AP, de Fátima Oliveira Santos S, Teixeira TM, da Silva PFF, Naves PLF, Batista AA, da Silva Oliveira RJ, Reis RM, de Paula Silveira-Lacerda E. Faria RS, et al. Among authors: batista aa. Biol Trace Elem Res. 2020 Dec;198(2):669-680. doi: 10.1007/s12011-020-02098-8. Epub 2020 Apr 8. Biol Trace Elem Res. 2020. PMID: 32266641
Cis-[RuCl(BzCN)(N-N)(P-P)]PF6 complexes: Synthesis and in vitro antitumor activity: (BzCN=benzonitrile; N-N=2,2'-bipyridine; 1,10-phenanthroline; P-P=1,4-bis(diphenylphosphino) butane, 1,2-bis(diphenylphosphino)ethane, or 1,1'-(diphenylphosphino)ferrocene).
Pereira Fde C, Lima BA, de Lima AP, Pires WC, Monteiro T, Magalhães LF, Costa W, Graminha AE, Batista AA, Ellena J, Siveira-Lacerda Ede P. Pereira Fde C, et al. Among authors: batista aa. J Inorg Biochem. 2015 Aug;149:91-101. doi: 10.1016/j.jinorgbio.2015.03.011. Epub 2015 Mar 31. J Inorg Biochem. 2015. PMID: 25873134
Ru(II)/diphenylphosphine/pyridine-6-thiolate complexes induce S-180 cell apoptosis through intrinsic mitochondrial pathway involving inhibition of Bcl-2 and p53/Bax activation.
Pires WC, Lima BAV, de Castro Pereira F, Lima AP, Mello-Andrade F, Silva HD, da Silva MM, Colina-Vegas L, Ellena J, Batista AA, de Paul Silveira-Lacerda E. Pires WC, et al. Among authors: batista aa. Mol Cell Biochem. 2018 Jan;438(1-2):199-217. doi: 10.1007/s11010-017-3129-3. Epub 2017 Aug 9. Mol Cell Biochem. 2018. PMID: 28795366
cis-[RuCl(BzCN)(bipy)(dppe)]PF6 induces anti-angiogenesis and apoptosis by a mechanism of caspase-dependent involving DNA damage, PARP activation, and Tp53 induction in Ehrlich tumor cells.
Magalhães LF, Mello-Andrade F, Pires WC, Silva HD, da Silva PFF, Macedo LM, Henrique de Castro C, Carneiro CC, Cardoso CG, de Melo Reis PR, Camargo de Oliveira L, Caetano RR, Batista AA, Silveira-Lacerda EP. Magalhães LF, et al. Among authors: batista aa. Chem Biol Interact. 2017 Dec 25;278:101-113. doi: 10.1016/j.cbi.2017.09.013. Epub 2017 Sep 19. Chem Biol Interact. 2017. PMID: 28935426
Antitumor effectiveness and mechanism of action of Ru(II)/amino acid/diphosphine complexes in the peritoneal carcinomatosis progression.
Mello-Andrade F, da Costa WL, Pires WC, Pereira FC, Cardoso CG, Lino-Junior RS, Irusta VRC, Carneiro CC, de Melo-Reis PR, Castro CH, Almeida MAP, Batista AA, Silveira-Lacerda EP. Mello-Andrade F, et al. Among authors: batista aa. Tumour Biol. 2017 Oct;39(10):1010428317695933. doi: 10.1177/1010428317695933. Tumour Biol. 2017. PMID: 29019283 Free article.
Acute toxic effects of ruthenium (II)/amino acid/diphosphine complexes on Swiss mice and zebrafish embryos.
Mello-Andrade F, Cardoso CG, Silva CRE, Chen-Chen L, Melo-Reis PR, Lima AP, Oliveira R, Ferraz IBM, Grisolia CK, Almeida MAP, Batista AA, Silveira-Lacerda EP. Mello-Andrade F, et al. Among authors: batista aa. Biomed Pharmacother. 2018 Nov;107:1082-1092. doi: 10.1016/j.biopha.2018.08.051. Epub 2018 Aug 25. Biomed Pharmacother. 2018. PMID: 30257320
In vitro cytotoxicity and in vivo zebrafish toxicity evaluation of Ru(ii)/2-mercaptopyrimidine complexes.
Velozo-Sá VS , Pereira LR , Lima AP , Mello-Andrade F , Rezende MRM , Goveia RM , Pires WC , Silva MM , Oliveira KM , Ferreira AG , Ellena J , Deflon VM , Grisolia CK , Batista AA , Silveira-Lacerda EP . Velozo-Sá VS , et al. Among authors: batista aa. Dalton Trans. 2019 May 7;48(18):6026-6039. doi: 10.1039/c8dt03738h. Dalton Trans. 2019. PMID: 30724926
Ruthenium(II) complexes with 6-methyl-2-thiouracil selectively reduce cell proliferation, cause DNA double-strand break and trigger caspase-mediated apoptosis through JNK/p38 pathways in human acute promyelocytic leukemia cells.
Bomfim LM, de Araujo FA, Dias RB, Sales CBS, Rocha CAG, Correa RS, Soares MBP, Batista AA, Bezerra DP. Bomfim LM, et al. Among authors: batista aa. Sci Rep. 2019 Aug 7;9(1):11483. doi: 10.1038/s41598-019-47914-x. Sci Rep. 2019. PMID: 31391500 Free PMC article.
148 results