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Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects.
Tomasovic A, Brand T, Schanbacher C, Kramer S, Hümmert MW, Godoy P, Schmidt-Heck W, Nordbeck P, Ludwig J, Homann S, Wiegering A, Shaykhutdinov T, Kratz C, Knüchel R, Müller-Hermelink HK, Rosenwald A, Frey N, Eichler J, Dobrev D, El-Armouche A, Hengstler JG, Müller OJ, Hinrichs K, Cuello F, Zernecke A, Lorenz K. Tomasovic A, et al. Among authors: homann s. Nat Commun. 2020 Apr 7;11(1):1733. doi: 10.1038/s41467-020-15505-4. Nat Commun. 2020. PMID: 32265441 Free PMC article.
Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage.
Bartolomaeus H, Balogh A, Yakoub M, Homann S, Markó L, Höges S, Tsvetkov D, Krannich A, Wundersitz S, Avery EG, Haase N, Kräker K, Hering L, Maase M, Kusche-Vihrog K, Grandoch M, Fielitz J, Kempa S, Gollasch M, Zhumadilov Z, Kozhakhmetov S, Kushugulova A, Eckardt KU, Dechend R, Rump LC, Forslund SK, Müller DN, Stegbauer J, Wilck N. Bartolomaeus H, et al. Among authors: homann s. Circulation. 2019 Mar 12;139(11):1407-1421. doi: 10.1161/CIRCULATIONAHA.118.036652. Circulation. 2019. PMID: 30586752 Free PMC article.
Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice.
Kiene LS, Homann S, Suvorava T, Rabausch B, Müller J, Kojda G, Kretschmer I, Twarock S, Dai G, Deenen R, Hartwig S, Lehr S, Köhrer K, Savani RC, Grandoch M, Fischer JW. Kiene LS, et al. Among authors: homann s. Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):e9-16. doi: 10.1161/ATVBAHA.115.306607. Epub 2015 Nov 19. Arterioscler Thromb Vasc Biol. 2016. PMID: 26586662 Free PMC article.
Cardiac Hyaluronan Synthesis Is Critically Involved in the Cardiac Macrophage Response and Promotes Healing After Ischemia Reperfusion Injury.
Petz A, Grandoch M, Gorski DJ, Abrams M, Piroth M, Schneckmann R, Homann S, Müller J, Hartwig S, Lehr S, Yamaguchi Y, Wight TN, Gorressen S, Ding Z, Kötter S, Krüger M, Heinen A, Kelm M, Gödecke A, Flögel U, Fischer JW. Petz A, et al. Among authors: homann s. Circ Res. 2019 May 10;124(10):1433-1447. doi: 10.1161/CIRCRESAHA.118.313285. Circ Res. 2019. PMID: 30916618
Hyaluronan synthase 3 promotes plaque inflammation and atheroprogression.
Homann S, Grandoch M, Kiene LS, Podsvyadek Y, Feldmann K, Rabausch B, Nagy N, Lehr S, Kretschmer I, Oberhuber A, Bollyky P, Fischer JW. Homann S, et al. Matrix Biol. 2018 Mar;66:67-80. doi: 10.1016/j.matbio.2017.09.005. Epub 2017 Oct 5. Matrix Biol. 2018. PMID: 28987865 Free PMC article.
Deficiency in lymphotoxin β receptor protects from atherosclerosis in apoE-deficient mice.
Grandoch M, Feldmann K, Göthert JR, Dick LS, Homann S, Klatt C, Bayer JK, Waldheim JN, Rabausch B, Nagy N, Oberhuber A, Deenen R, Köhrer K, Lehr S, Homey B, Pfeffer K, Fischer JW. Grandoch M, et al. Among authors: homann s. Circ Res. 2015 Apr 10;116(8):e57-68. doi: 10.1161/CIRCRESAHA.116.305723. Epub 2015 Mar 4. Circ Res. 2015. PMID: 25740843
Loss of Biglycan Enhances Thrombin Generation in Apolipoprotein E-Deficient Mice: Implications for Inflammation and Atherosclerosis.
Grandoch M, Kohlmorgen C, Melchior-Becker A, Feldmann K, Homann S, Müller J, Kiene LS, Zeng-Brouwers J, Schmitz F, Nagy N, Polzin A, Gowert NS, Elvers M, Skroblin P, Yin X, Mayr M, Schaefer L, Tannock LR, Fischer JW. Grandoch M, et al. Among authors: homann s. Arterioscler Thromb Vasc Biol. 2016 May;36(5):e41-50. doi: 10.1161/ATVBAHA.115.306973. Epub 2016 Mar 31. Arterioscler Thromb Vasc Biol. 2016. PMID: 27034473
SMC-Derived Hyaluronan Modulates Vascular SMC Phenotype in Murine Atherosclerosis.
Hartmann F, Gorski DJ, Newman AAC, Homann S, Petz A, Owsiany KM, Serbulea V, Zhou YQ, Deaton RA, Bendeck M, Owens GK, Fischer JW. Hartmann F, et al. Among authors: homann s. Circ Res. 2021 Nov 12;129(11):992-1005. doi: 10.1161/CIRCRESAHA.120.318479. Epub 2021 Oct 7. Circ Res. 2021. PMID: 34615369 Free PMC article.
39 results