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Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects.
Tomasovic A, Brand T, Schanbacher C, Kramer S, Hümmert MW, Godoy P, Schmidt-Heck W, Nordbeck P, Ludwig J, Homann S, Wiegering A, Shaykhutdinov T, Kratz C, Knüchel R, Müller-Hermelink HK, Rosenwald A, Frey N, Eichler J, Dobrev D, El-Armouche A, Hengstler JG, Müller OJ, Hinrichs K, Cuello F, Zernecke A, Lorenz K. Tomasovic A, et al. Among authors: cuello f. Nat Commun. 2020 Apr 7;11(1):1733. doi: 10.1038/s41467-020-15505-4. Nat Commun. 2020. PMID: 32265441 Free PMC article.
Heart failure-specific changes in protein kinase signalling.
Lorenz K, Stathopoulou K, Schmid E, Eder P, Cuello F. Lorenz K, et al. Among authors: cuello f. Pflugers Arch. 2014 Jun;466(6):1151-62. doi: 10.1007/s00424-014-1462-x. Epub 2014 Feb 8. Pflugers Arch. 2014. PMID: 24510065 Review.
S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure.
Stathopoulou K, Wittig I, Heidler J, Piasecki A, Richter F, Diering S, van der Velden J, Buck F, Donzelli S, Schröder E, Wijnker PJ, Voigt N, Dobrev D, Sadayappan S, Eschenhagen T, Carrier L, Eaton P, Cuello F. Stathopoulou K, et al. Among authors: cuello f. FASEB J. 2016 May;30(5):1849-64. doi: 10.1096/fj.201500048. Epub 2016 Feb 2. FASEB J. 2016. PMID: 26839380 Free PMC article.
-Stathopoulou, K., Wittig, I., Heidler, J., Piasecki, A., Richter, F., Diering, S., van der Velden, J., Buck, F., Donzelli, S., Schroder, E., Wijnker, P. ...M., Voigt, N., Dobrev, D., Sadayappan, S., Eschenhagen, T., Carrier, L., Eaton, P., Cuello, F. …
-Stathopoulou, K., Wittig, I., Heidler, J., Piasecki, A., Richter, F., Diering, S., van der Velden, J., Buck, F., Donzelli, S. …
Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response.
Scotcher J, Prysyazhna O, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O, Rodriguez Cutillas P, Cuello F, Shattock MJ, Marber MS, Conte MR, Greenstein A, Greensmith DJ, Venetucci L, Timms JF, Eaton P. Scotcher J, et al. Among authors: cuello f. Nat Commun. 2016 Oct 26;7:13187. doi: 10.1038/ncomms13187. Nat Commun. 2016. PMID: 27782102 Free PMC article.
Analysis of fibrosis in control or pressure overloaded rat hearts after mechanical unloading by heterotopic heart transplantation.
Schaefer A, Schneeberger Y, Schulz S, Krasemann S, Werner T, Piasecki A, Höppner G, Müller C, Morhenn K, Lorenz K, Wieczorek D, Schwoerer AP, Eschenhagen T, Ehmke H, Reichenspurner H, Stenzig J, Cuello F. Schaefer A, et al. Among authors: cuello f. Sci Rep. 2019 Apr 5;9(1):5710. doi: 10.1038/s41598-019-42263-1. Sci Rep. 2019. PMID: 30952943 Free PMC article.
Sulforaphane exposure impairs contractility and mitochondrial function in three-dimensional engineered heart tissue.
Rhoden A, Friedrich FW, Brandt T, Raabe J, Schweizer M, Meisterknecht J, Wittig I, Ulmer BM, Klampe B, Uebeler J, Piasecki A, Lorenz K, Eschenhagen T, Hansen A, Cuello F. Rhoden A, et al. Among authors: cuello f. Redox Biol. 2021 May;41:101951. doi: 10.1016/j.redox.2021.101951. Epub 2021 Mar 31. Redox Biol. 2021. PMID: 33831709 Free PMC article.
84 results