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The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission.
Vega-Rodríguez J, Franke-Fayard B, Dinglasan RR, Janse CJ, Pastrana-Mena R, Waters AP, Coppens I, Rodríguez-Orengo JF, Srinivasan P, Jacobs-Lorena M, Serrano AE. Vega-Rodríguez J, et al. Among authors: serrano ae. PLoS Pathog. 2009 Feb;5(2):e1000302. doi: 10.1371/journal.ppat.1000302. Epub 2009 Feb 20. PLoS Pathog. 2009. PMID: 19229315 Free PMC article.
Glutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquito.
Pastrana-Mena R, Dinglasan RR, Franke-Fayard B, Vega-Rodríguez J, Fuentes-Caraballo M, Baerga-Ortiz A, Coppens I, Jacobs-Lorena M, Janse CJ, Serrano AE. Pastrana-Mena R, et al. Among authors: serrano ae. J Biol Chem. 2010 Aug 27;285(35):27045-27056. doi: 10.1074/jbc.M110.122275. Epub 2010 Jun 23. J Biol Chem. 2010. PMID: 20573956 Free PMC article.
Antimalarial Drug Combination Predictions Using the Machine Learning Synergy Predictor (MLSyPred©) tool.
Roche-Lima A, Rosado-Quiñones AM, Feliu-Maldonado RA, Figueroa-Gispert MDM, Díaz-Rivera J, Díaz-González RG, Carrasquillo-Carrion K, Nieves BG, Colón-Lorenzo EE, Serrano AE. Roche-Lima A, et al. Among authors: serrano ae. Acta Parasitol. 2024 Mar;69(1):415-425. doi: 10.1007/s11686-023-00765-z. Epub 2024 Jan 2. Acta Parasitol. 2024. PMID: 38165555 Free PMC article.
Novel hydrazone compounds with broad-spectrum antiplasmodial activity and synergistic interactions with antimalarial drugs.
Rosado-Quiñones AM, Colón-Lorenzo EE, Pala ZR, Bosch J, Kudyba K, Kudyba H, Leed SE, Roncal N, Baerga-Ortiz A, Roche-Lima A, Gerena Y, Fidock DA, Roth A, Vega-Rodríguez J, Serrano AE. Rosado-Quiñones AM, et al. Among authors: serrano ae. Antimicrob Agents Chemother. 2024 Apr 19:e0164323. doi: 10.1128/aac.01643-23. Online ahead of print. Antimicrob Agents Chemother. 2024. PMID: 38639491 Free article.
41 results