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Dual Action Calcium-Sensing Receptor Modulator Unmasks Novel Mode-Switching Mechanism.
Gregory KJ, Kufareva I, Keller AN, Khajehali E, Mun HC, Goolam MA, Mason RS, Capuano B, Conigrave AD, Christopoulos A, Leach K. Gregory KJ, et al. Among authors: khajehali e. ACS Pharmacol Transl Sci. 2018 Sep 12;1(2):96-109. doi: 10.1021/acsptsci.8b00021. eCollection 2018 Nov 9. ACS Pharmacol Transl Sci. 2018. PMID: 32219206 Free PMC article.
Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles.
Dallagnol JCC, Khajehali E, van der Westhuizen ET, Jörg M, Valant C, Gonçalves AG, Capuano B, Christopoulos A, Scammells PJ. Dallagnol JCC, et al. Among authors: khajehali e. J Med Chem. 2018 Apr 12;61(7):2875-2894. doi: 10.1021/acs.jmedchem.7b01812. Epub 2018 Mar 23. J Med Chem. 2018. PMID: 29544056
Assessment of the Molecular Mechanisms of Action of Novel 4-Phenylpyridine-2-One and 6-Phenylpyrimidin-4-One Allosteric Modulators at the M1 Muscarinic Acetylcholine Receptors.
van der Westhuizen ET, Spathis A, Khajehali E, Jörg M, Mistry SN, Capuano B, Tobin AB, Sexton PM, Scammells PJ, Valant C, Christopoulos A. van der Westhuizen ET, et al. Among authors: khajehali e. Mol Pharmacol. 2018 Jul;94(1):770-783. doi: 10.1124/mol.118.111633. Epub 2018 Apr 24. Mol Pharmacol. 2018. PMID: 29691279
DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo.
Thompson KJ, Khajehali E, Bradley SJ, Navarrete JS, Huang XP, Slocum S, Jin J, Liu J, Xiong Y, Olsen RHJ, Diberto JF, Boyt KM, Pina MM, Pati D, Molloy C, Bundgaard C, Sexton PM, Kash TL, Krashes MJ, Christopoulos A, Roth BL, Tobin AB. Thompson KJ, et al. Among authors: khajehali e. ACS Pharmacol Transl Sci. 2018 Sep 14;1(1):61-72. doi: 10.1021/acsptsci.8b00012. Epub 2018 Jul 27. ACS Pharmacol Transl Sci. 2018. PMID: 30868140 Free PMC article.
Development of Novel 4-Arylpyridin-2-one and 6-Arylpyrimidin-4-one Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor.
Jörg M, Khajehali E, van der Westhuizen ET, C Choy KH, Shackleford DM, Tobin AB, Sexton PM, Valant C, Capuano B, Christopoulos A, Scammells PJ. Jörg M, et al. Among authors: khajehali e. ChemMedChem. 2021 Jan 8;16(1):216-233. doi: 10.1002/cmdc.202000540. Epub 2020 Sep 25. ChemMedChem. 2021. PMID: 32851779 Free article.
19 results