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Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo.
Desaphy JF, Farinato A, Altamura C, De Bellis M, Imbrici P, Tarantino N, Caccia C, Melloni E, Padoani G, Vailati S, Keywood C, Carratù MR, De Luca A, Conte D, Pierno S. Desaphy JF, et al. Among authors: farinato a. Exp Neurol. 2020 Jun;328:113287. doi: 10.1016/j.expneurol.2020.113287. Epub 2020 Mar 20. Exp Neurol. 2020. PMID: 32205118
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity.
De Bellis M, Carbonara R, Roussel J, Farinato A, Massari A, Pierno S, Muraglia M, Corbo F, Franchini C, Carratù MR, De Luca A, Conte Camerino D, Desaphy JF. De Bellis M, et al. Among authors: farinato a. Neuropharmacology. 2017 Feb;113(Pt A):206-216. doi: 10.1016/j.neuropharm.2016.10.013. Epub 2016 Oct 13. Neuropharmacology. 2017. PMID: 27743929 Free PMC article.
Coexistence of CLCN1 and SCN4A mutations in one family suffering from myotonia.
Maggi L, Ravaglia S, Farinato A, Brugnoni R, Altamura C, Imbrici P, Camerino DC, Padovani A, Mantegazza R, Bernasconi P, Desaphy JF, Filosto M. Maggi L, et al. Among authors: farinato a. Neurogenetics. 2017 Dec;18(4):219-225. doi: 10.1007/s10048-017-0525-5. Epub 2017 Oct 9. Neurogenetics. 2017. PMID: 28993909
Mapping ligand binding pockets in chloride ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid.
Altamura C, Mangiatordi GF, Nicolotti O, Sahbani D, Farinato A, Leonetti F, Carratù MR, Conte D, Desaphy JF, Imbrici P. Altamura C, et al. Among authors: farinato a. Br J Pharmacol. 2018 May;175(10):1770-1780. doi: 10.1111/bph.14192. Epub 2018 Apr 6. Br J Pharmacol. 2018. PMID: 29500929 Free PMC article.
Development of Riluzole Analogs with Improved Use-Dependent Inhibition of Skeletal Muscle Sodium Channels.
Farinato A, Cavalluzzi MM, Altamura C, Campanale C, Laghetti P, Saltarella I, Delre P, Barbault A, Tarantino N, Milani G, Rotondo NP, Di Cesare Mannelli L, Ghelardini C, Pierno S, Mangiatordi GF, Lentini G, Desaphy JF. Farinato A, et al. ACS Med Chem Lett. 2023 Jun 23;14(7):999-1008. doi: 10.1021/acsmedchemlett.3c00224. eCollection 2023 Jul 13. ACS Med Chem Lett. 2023. PMID: 37465302