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Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia.
Hegde S, Gasilina A, Wunderlich M, Lin Y, Buchholzer M, Krumbach OHF, Akbarzadeh M, Ahmadian MR, Seibel W, Zheng Y, Perentesis JP, Mizukawa BE, Vinnedge LP, Cancelas JA, Nassar NN. Hegde S, et al. Leukemia. 2022 Mar;36(3):637-647. doi: 10.1038/s41375-021-01455-3. Epub 2021 Oct 28. Leukemia. 2022. PMID: 34711926 Free PMC article.
TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma.
Hall DP, Cost NG, Hegde S, Kellner E, Mikhaylova O, Stratton Y, Ehmer B, Abplanalp WA, Pandey R, Biesiada J, Harteneck C, Plas DR, Meller J, Czyzyk-Krzeska MF. Hall DP, et al. Among authors: hegde s. Cancer Cell. 2014 Nov 10;26(5):738-53. doi: 10.1016/j.ccell.2014.09.015. Epub 2014 Nov 10. Cancer Cell. 2014. PMID: 25517751 Free PMC article.
Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics.
Serrano-Lopez J, Hegde S, Kumar S, Serrano J, Fang J, Wellendorf AM, Roche PA, Rangel Y, Carrington LJ, Geiger H, Grimes HL, Luther S, Maillard I, Sanchez-Garcia J, Starczynowski DT, Cancelas JA. Serrano-Lopez J, et al. Among authors: hegde s. Elife. 2021 Apr 8;10:e66190. doi: 10.7554/eLife.66190. Elife. 2021. PMID: 33830019 Free PMC article.
When the body becomes infected with disease-causing pathogens, such as bacteria, the immune system activates various mechanisms which help to fight off the infection. One of the immune system's first lines of defense is to launch an inflammatory response that helps remove …
When the body becomes infected with disease-causing pathogens, such as bacteria, the immune system activates various mechanisms which help t …
1,136 results