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Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes.
Latorre J, Ortega FJ, Liñares-Pose L, Moreno-Navarrete JM, Lluch A, Comas F, Oliveras-Cañellas N, Ricart W, Höring M, Zhou Y, Liebisch G, Nidhina Haridas PA, Olkkonen VM, López M, Fernández-Real JM. Latorre J, et al. Among authors: zhou y. EBioMedicine. 2020 Mar;53:102697. doi: 10.1016/j.ebiom.2020.102697. Epub 2020 Mar 3. EBioMedicine. 2020. PMID: 32143184 Free PMC article.
PNPLA3 mediates hepatocyte triacylglycerol remodeling.
Ruhanen H, Perttilä J, Hölttä-Vuori M, Zhou Y, Yki-Järvinen H, Ikonen E, Käkelä R, Olkkonen VM. Ruhanen H, et al. Among authors: zhou y. J Lipid Res. 2014 Apr;55(4):739-46. doi: 10.1194/jlr.M046607. Epub 2014 Feb 7. J Lipid Res. 2014. PMID: 24511104 Free PMC article.
Novel hepatic microRNAs upregulated in human nonalcoholic fatty liver disease.
Soronen J, Yki-Järvinen H, Zhou Y, Sädevirta S, Sarin AP, Leivonen M, Sevastianova K, Perttilä J, Laurila PP, Sigruener A, Schmitz G, Olkkonen VM. Soronen J, et al. Among authors: zhou y. Physiol Rep. 2016 Jan;4(1):e12661. doi: 10.14814/phy2.12661. Physiol Rep. 2016. PMID: 26733244 Free PMC article.
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