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Identification and analyses of inhibitors targeting apolipoprotein(a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function.
Sandmark J, Tigerström A, Akerud T, Althage M, Antonsson T, Blaho S, Bodin C, Boström J, Chen Y, Dahlén A, Eriksson PO, Evertsson E, Fex T, Fjellström O, Gustafsson D, Herslöf M, Hicks R, Jarkvist E, Johansson C, Kalies I, Karlsson Svalstedt B, Kartberg F, Legnehed A, Martinsson S, Moberg A, Ridderström M, Rosengren B, Sabirsh A, Thelin A, Vinblad J, Wellner AU, Xu B, Östlund-Lindqvist AM, Knecht W. Sandmark J, et al. Among authors: chen y. J Biol Chem. 2020 Apr 10;295(15):5136-5151. doi: 10.1074/jbc.RA119.011251. Epub 2020 Mar 4. J Biol Chem. 2020. PMID: 32132173 Free PMC article.
Identification of novel GPR81 agonist lead series for target biology evaluation.
Davidsson Ö, Nilsson K, Brånalt J, Andersson T, Berggren K, Chen Y, Fjellström O, Gradén H, Gustafsson L, Hermansson NO, Jansen F, Johannesson P, Ohlsson B, Tyrchan C, Wellner A, Wellner E, Ölwegård-Halvarsson M. Davidsson Ö, et al. Among authors: chen y. Bioorg Med Chem Lett. 2020 Feb 15;30(4):126953. doi: 10.1016/j.bmcl.2020.126953. Epub 2020 Jan 7. Bioorg Med Chem Lett. 2020. PMID: 31932225
Selective PPARγ modulator diosmin improves insulin sensitivity and promotes browning of white fat.
Yu J, Hu Y, Sheng M, Gao M, Guo W, Zhang Z, Wang D, Wu X, Li J, Chen Y, Zhao W, Liu C, Cui X, Chen X, Zhao C, Chen H, Xiao J, Chen S, Luo C, Xu L, Gu X, Ma X. Yu J, et al. Among authors: chen s, chen x, chen h, chen y. J Biol Chem. 2023 Apr;299(4):103059. doi: 10.1016/j.jbc.2023.103059. Epub 2023 Feb 24. J Biol Chem. 2023. PMID: 36841479 Free PMC article.
High-Throughput-Methyl-Reading (HTMR) assay: a solution based on nucleotide methyl-binding proteins enables large-scale screening for DNA/RNA methyltransferases and demethylases.
Xiao S, Guo S, Han J, Sun Y, Wang M, Chen Y, Fang X, Yang F, Mu Y, Zhang L, Ding Y, Zhang N, Jiang H, Chen K, Zhao K, Luo C, Chen S. Xiao S, et al. Among authors: chen k, chen s, chen y. Nucleic Acids Res. 2022 Jan 25;50(2):e9. doi: 10.1093/nar/gkab989. Nucleic Acids Res. 2022. PMID: 34718755 Free PMC article.
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