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Identification and analyses of inhibitors targeting apolipoprotein(a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function.
J Biol Chem. 2020 Apr 10;295(15):5136-5151. doi: 10.1074/jbc.RA119.011251. Epub 2020 Mar 4.
J Biol Chem. 2020.
PMID: 32132173
Free PMC article.
Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.
Bengtsson C, Blaho S, Saitton DB, Brickmann K, Broddefalk J, Davidsson O, Drmota T, Folmer R, Hallberg K, Hallén S, Hovland R, Isin E, Johannesson P, Kull B, Larsson LO, Löfgren L, Nilsson KE, Noeske T, Oakes N, Plowright AT, Schnecke V, Ståhlberg P, Sörme P, Wan H, Wellner E, Oster L.
Bengtsson C, et al. Among authors: blaho s.
Bioorg Med Chem. 2011 May 15;19(10):3039-53. doi: 10.1016/j.bmc.2011.04.014. Epub 2011 Apr 13.
Bioorg Med Chem. 2011.
PMID: 21515056
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A class of highly selective inhibitors bind to an active state of PI3Kγ.
Gangadhara G, Dahl G, Bohnacker T, Rae R, Gunnarsson J, Blaho S, Öster L, Lindmark H, Karabelas K, Pemberton N, Tyrchan C, Mogemark M, Wymann MP, Williams RL, Perry MWD, Papavoine T, Petersen J.
Gangadhara G, et al. Among authors: blaho s.
Nat Chem Biol. 2019 Apr;15(4):348-357. doi: 10.1038/s41589-018-0215-0. Epub 2019 Feb 4.
Nat Chem Biol. 2019.
PMID: 30718815
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Avidity-Based Affinity Enhancement Using Nanoliposome-Amplified SPR Sensing Enables Low Picomolar Detection of Biologically Active Neuregulin 1.
Akkilic N, Liljeblad M, Blaho S, Hölttä M, Höök F, Geschwindner S.
Akkilic N, et al. Among authors: blaho s.
ACS Sens. 2019 Dec 27;4(12):3166-3174. doi: 10.1021/acssensors.9b01392. Epub 2019 Nov 27.
ACS Sens. 2019.
PMID: 31724395
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