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The Coup-TFII orphan nuclear receptor is an activator of the γ-globin gene.
Fugazza C, Barbarani G, Elangovan S, Marini MG, Giolitto S, Font-Monclus I, Marongiu MF, Manunza L, Strouboulis J, Cantù C, Gasparri F, Barabino SML, Nakamura Y, Ottolenghi S, Moi P, Ronchi AE. Fugazza C, et al. Among authors: nakamura y. Haematologica. 2021 Feb 1;106(2):474-482. doi: 10.3324/haematol.2019.241224. Haematologica. 2021. PMID: 32107331 Free PMC article.
Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL.
Trakarnsanga K, Wilson MC, Lau W, Singleton BK, Parsons SF, Sakuntanaga P, Kurita R, Nakamura Y, Anstee DJ, Frayne J. Trakarnsanga K, et al. Among authors: nakamura y. Haematologica. 2014 Nov;99(11):1677-85. doi: 10.3324/haematol.2014.110155. Epub 2014 Aug 8. Haematologica. 2014. PMID: 25107887 Free PMC article.
Inclusion of a short hairpin RNA targeting BCL11A into a β-globin expressing vector allows concurrent synthesis of curative adult and fetal hemoglobin.
Pires Lourenco S, Jarocha D, Ghiaccio V, Guerra A, Abdulmalik O, La P, Zezulin A, Smith-Whitley K, Kwiatkowski JL, Guzikowski V, Nakamura Y, Raabe T, Breda L, Rivella S. Pires Lourenco S, et al. Among authors: nakamura y. Haematologica. 2021 Oct 1;106(10):2740-2745. doi: 10.3324/haematol.2020.276634. Haematologica. 2021. PMID: 34047176 Free PMC article. No abstract available.
RUNX3 levels in human hematopoietic progenitors are regulated by aging and dictate erythroid-myeloid balance.
Balogh P, Adelman ER, Pluvinage JV, Capaldo BJ, Freeman KC, Singh S, Elagib KE, Nakamura Y, Kurita R, Sashida G, Zunder ER, Li H, Gru AA, Price EA, Schrier SL, Weissman IL, Figueroa ME, Pang WW, Goldfarb AN. Balogh P, et al. Among authors: nakamura y. Haematologica. 2020 Apr;105(4):905-913. doi: 10.3324/haematol.2018.208918. Epub 2019 Jun 6. Haematologica. 2020. PMID: 31171641 Free PMC article.
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