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A mouse model of MSU-induced acute inflammation in vivo suggests imiquimod-dependent targeting of Il-1β as relevant therapy for gout patients.
Mariotte A, De Cauwer A, Po C, Abou-Faycal C, Pichot A, Paul N, Aouadi I, Carapito R, Frisch B, Macquin C, Chatelus E, Sibilia J, Armspach JP, Bahram S, Georgel P. Mariotte A, et al. Among authors: abou faycal c. Theranostics. 2020 Jan 12;10(5):2158-2171. doi: 10.7150/thno.40650. eCollection 2020. Theranostics. 2020. PMID: 32104502 Free PMC article.
A Translational Investigation of IFN-α and STAT1 Signaling in Endothelial Cells during Septic Shock Provides Therapeutic Perspectives.
Clere-Jehl R, Merdji H, Kassem M, Macquin C, De Cauwer A, Sibony A, Kurihara K, Minniti L, Abou Fayçal C, Bahram S, Meziani F, Helms J, Georgel P. Clere-Jehl R, et al. Among authors: abou faycal c. Am J Respir Cell Mol Biol. 2021 Aug;65(2):167-175. doi: 10.1165/rcmb.2020-0401OC. Am J Respir Cell Mol Biol. 2021. PMID: 33798037
Impact of Tenascin-C on Radiotherapy in a Novel Syngeneic Oral Squamous Cell Carcinoma Model With Spontaneous Dissemination to the Lymph Nodes.
Spenlé C, Loustau T, Burckel H, Riegel G, Abou Faycal C, Li C, Yilmaz A, Petti L, Steinbach F, Ahowesso C, Jost C, Paul N, Carapito R, Noël G, Anjuère F, Salomé N, Orend G. Spenlé C, et al. Among authors: abou faycal c. Front Immunol. 2021 Jul 5;12:636108. doi: 10.3389/fimmu.2021.636108. eCollection 2021. Front Immunol. 2021. PMID: 34290694 Free PMC article.
Tenascin-C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression.
Murdamoothoo D, Sun Z, Yilmaz A, Riegel G, Abou-Faycal C, Deligne C, Velazquez-Quesada I, Erne W, Nascimento M, Mörgelin M, Cremel G, Paul N, Carapito R, Veber R, Dumortier H, Yuan J, Midwood KS, Loustau T, Orend G. Murdamoothoo D, et al. Among authors: abou faycal c. EMBO Mol Med. 2021 Jun 7;13(6):e13270. doi: 10.15252/emmm.202013270. Epub 2021 May 14. EMBO Mol Med. 2021. PMID: 33988305 Free PMC article.
Tenascin-C increases lung metastasis by impacting blood vessel invasions.
Sun Z, Velázquez-Quesada I, Murdamoothoo D, Ahowesso C, Yilmaz A, Spenlé C, Averous G, Erne W, Oberndorfer F, Oszwald A, Kain R, Bourdon C, Mangin P, Deligne C, Midwood K, Abou-Faycal C, Lefebvre O, Klein A, van der Heyden M, Chenard MP, Christofori G, Mathelin C, Loustau T, Hussenet T, Orend G. Sun Z, et al. Among authors: abou faycal c. Matrix Biol. 2019 Oct;83:26-47. doi: 10.1016/j.matbio.2019.07.001. Epub 2019 Jul 6. Matrix Biol. 2019. PMID: 31288084 Free article.
Modulating tenascin-C functions by targeting the MAtrix REgulating MOtif, "MAREMO".
Loustau T, Abou-Faycal C, Erne W, Zur Wiesch PA, Ksouri A, Imhof T, Mörgelin M, Li C, Mathieu M, Salomé N, Crémel G, Dhaouadi S, Bouhaouala-Zahar B, Koch M, Orend G. Loustau T, et al. Among authors: abou faycal c. Matrix Biol. 2022 Apr;108:20-38. doi: 10.1016/j.matbio.2022.02.007. Epub 2022 Feb 26. Matrix Biol. 2022. PMID: 35227929
Novel Human Tenascin-C Function-Blocking Camel Single Domain Nanobodies.
Dhaouadi S, Ben Abderrazek R, Loustau T, Abou-Faycal C, Ksouri A, Erne W, Murdamoothoo D, Mörgelin M, Kungl A, Jung A, Ledrappier S, Benlasfar Z, Bichet S, Chiquet-Ehrismann R, Hendaoui I, Orend G, Bouhaouala-Zahar B. Dhaouadi S, et al. Among authors: abou faycal c. Front Immunol. 2021 Mar 15;12:635166. doi: 10.3389/fimmu.2021.635166. eCollection 2021. Front Immunol. 2021. PMID: 33790905 Free PMC article.
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