Eastwood D - Search Results

1

Higher mass meningococcal group C-tetanus toxoid vaccines conjugated with carbodiimide correlate with greater immunogenicity.

Lockyer K, Gao F, Francis RJ, Eastwood D, Khatri B, Stebbings R, Derrick JP, Bolgiano B. Lockyer K, et al. Among authors: eastwood d. Vaccine. 2020 Mar 17;38(13):2859-2869. doi: 10.1016/j.vaccine.2020.02.012. Epub 2020 Feb 20. Vaccine. 2020. PMID: 32089463 Free article.

2

How predictive are in vitro assays for cytokine release syndrome in vivo? A comparison of methods reveals worrying differences in sensitivity and frequency of response.

Thorpe SJ, Stebbings R, Findlay L, Eastwood D, Poole S, Thorpe R. Thorpe SJ, et al. Among authors: eastwood d. Cytokine. 2013 Oct;64(1):471-2. doi: 10.1016/j.cyto.2013.07.009. Epub 2013 Jul 30. Cytokine. 2013. PMID: 23910011 No abstract available.

3

After TGN1412: recent developments in cytokine release assays.

Stebbings R, Eastwood D, Poole S, Thorpe R. Stebbings R, et al. Among authors: eastwood d. J Immunotoxicol. 2013 Jan-Mar;10(1):75-82. doi: 10.3109/1547691X.2012.711783. Epub 2012 Sep 11. J Immunotoxicol. 2013. PMID: 22967038 Free PMC article.

4

Improved in vitro methods to predict the in vivo toxicity in man of therapeutic monoclonal antibodies including TGN1412.

Findlay L, Eastwood D, Stebbings R, Sharp G, Mistry Y, Ball C, Hood J, Thorpe R, Poole S. Findlay L, et al. Among authors: eastwood d. J Immunol Methods. 2010 Jan 31;352(1-2):1-12. doi: 10.1016/j.jim.2009.10.013. Epub 2009 Nov 4. J Immunol Methods. 2010. PMID: 19895813

5

Comparison of novel methods for predicting the risk of pro-inflammatory clinical infusion reactions during monoclonal antibody therapy.

Findlay L, Eastwood D, Ball C, Robinson CJ, Bird C, Wadhwa M, Thorpe SJ, Thorpe R, Stebbings R, Poole S. Findlay L, et al. Among authors: eastwood d. J Immunol Methods. 2011 Aug 31;371(1-2):134-42. doi: 10.1016/j.jim.2011.06.022. Epub 2011 Jun 30. J Immunol Methods. 2011. PMID: 21741383

6

Severity of the TGN1412 trial disaster cytokine storm correlated with IL-2 release.

Eastwood D, Bird C, Dilger P, Hockley J, Findlay L, Poole S, Thorpe SJ, Wadhwa M, Thorpe R, Stebbings R. Eastwood D, et al. Br J Clin Pharmacol. 2013 Aug;76(2):299-315. doi: 10.1111/bcp.12165. Br J Clin Pharmacol. 2013. PMID: 23701319 Free PMC article.

7

Endothelial cells co-stimulate peripheral blood mononuclear cell responses to monoclonal antibody TGN1412 in culture.

Findlay L, Sharp G, Fox B, Ball C, Robinson CJ, Bird C, Stebbings R, Eastwood D, Wadhwa M, Poole S, Thorpe R, Thorpe SJ. Findlay L, et al. Among authors: eastwood d. Cytokine. 2011 Jul;55(1):141-51. doi: 10.1016/j.cyto.2011.03.019. Epub 2011 Apr 13. Cytokine. 2011. PMID: 21493088

8

Antibody C region influences TGN1412-like functional activity in vitro.

Ball C, Fox B, Hufton S, Sharp G, Poole S, Stebbings R, Eastwood D, Findlay L, Parren PW, Thorpe R, Bristow A, Thorpe SJ. Ball C, et al. Among authors: eastwood d. J Immunol. 2012 Dec 15;189(12):5831-40. doi: 10.4049/jimmunol.1201795. Epub 2012 Nov 12. J Immunol. 2012. PMID: 23150712

9

Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells.

Eastwood D, Findlay L, Poole S, Bird C, Wadhwa M, Moore M, Burns C, Thorpe R, Stebbings R. Eastwood D, et al. Br J Pharmacol. 2010 Oct;161(3):512-26. doi: 10.1111/j.1476-5381.2010.00922.x. Br J Pharmacol. 2010. PMID: 20880392 Free PMC article.

10

Cytokine release assays for the prediction of therapeutic mAb safety in first-in man trials--Whole blood cytokine release assays are poorly predictive for TGN1412 cytokine storm.

Vessillier S, Eastwood D, Fox B, Sathish J, Sethu S, Dougall T, Thorpe SJ, Thorpe R, Stebbings R. Vessillier S, et al. Among authors: eastwood d. J Immunol Methods. 2015 Sep;424:43-52. doi: 10.1016/j.jim.2015.04.020. Epub 2015 May 7. J Immunol Methods. 2015. PMID: 25960173 Free PMC article.

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