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Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach.
Lorthiois E, Roache J, Barnes-Seeman D, Altmann E, Hassiepen U, Turner G, Duvadie R, Hornak V, Karki RG, Schiering N, Weihofen WA, Perruccio F, Calhoun A, Fazal T, Dedic D, Durand C, Dussauge S, Fettis K, Tritsch F, Dentel C, Druet A, Liu D, Kirman L, Lachal J, Namoto K, Bevan D, Mo R, Monnet G, Muller L, Zessis R, Huang X, Lindsley L, Currie T, Chiu YH, Fridrich C, Delgado P, Wang S, Hollis-Symynkywicz M, Berghausen J, Williams E, Liu H, Liang G, Kim H, Hoffmann P, Hein A, Ramage P, D'Arcy A, Harlfinger S, Renatus M, Ruedisser S, Feldman D, Elliott J, Sedrani R, Maibaum J, Adams CM. Lorthiois E, et al. Among authors: turner g. J Med Chem. 2020 Aug 13;63(15):8088-8113. doi: 10.1021/acs.jmedchem.0c00279. Epub 2020 Jul 21. J Med Chem. 2020. PMID: 32551603
Small-molecule WNK inhibition regulates cardiovascular and renal function.
Yamada K, Park HM, Rigel DF, DiPetrillo K, Whalen EJ, Anisowicz A, Beil M, Berstler J, Brocklehurst CE, Burdick DA, Caplan SL, Capparelli MP, Chen G, Chen W, Dale B, Deng L, Fu F, Hamamatsu N, Harasaki K, Herr T, Hoffmann P, Hu QY, Huang WJ, Idamakanti N, Imase H, Iwaki Y, Jain M, Jeyaseelan J, Kato M, Kaushik VK, Kohls D, Kunjathoor V, LaSala D, Lee J, Liu J, Luo Y, Ma F, Mo R, Mowbray S, Mogi M, Ossola F, Pandey P, Patel SJ, Raghavan S, Salem B, Shanado YH, Trakshel GM, Turner G, Wakai H, Wang C, Weldon S, Wielicki JB, Xie X, Xu L, Yagi YI, Yasoshima K, Yin J, Yowe D, Zhang JH, Zheng G, Monovich L. Yamada K, et al. Among authors: turner g. Nat Chem Biol. 2016 Nov;12(11):896-898. doi: 10.1038/nchembio.2168. Epub 2016 Sep 5. Nat Chem Biol. 2016. PMID: 27595330
Lack of authentic atrial fibrillation in commonly used murine atrial fibrillation models.
Fu F, Pietropaolo M, Cui L, Pandit S, Li W, Tarnavski O, Shetty SS, Liu J, Lussier JM, Murakami Y, Grewal PK, Deyneko G, Turner GM, Taggart AKP, Waters MG, Coughlin S, Adachi Y. Fu F, et al. Among authors: turner gm. PLoS One. 2022 Jan 7;17(1):e0256512. doi: 10.1371/journal.pone.0256512. eCollection 2022. PLoS One. 2022. PMID: 34995278 Free PMC article.
Aptamer Proteomics for Biomarker Discovery in Heart Failure With Reduced Ejection Fraction.
Zhang L, Cunningham JW, Claggett BL, Jacob J, Mendelson MM, Serrano-Fernandez P, Kaiser S, Yates DP, Healey M, Chen CW, Turner GM, Patel-Murray NL, Zhao F, Beste MT, Laramie JM, Abraham WT, Jhund PS, Kober L, Packer M, Rouleau J, Zile MR, Prescott MF, Lefkowitz M, McMurray JJV, Solomon SD, Chutkow W. Zhang L, et al. Circulation. 2022 Nov;146(18):1411-1414. doi: 10.1161/CIRCULATIONAHA.122.061481. Epub 2022 Aug 27. Circulation. 2022. PMID: 36029463 Free article. No abstract available.
Locus coeruleus integrity is related to an exploitation-based decision-making bias in older adulthood.
Turner GR, Hewan P, Wearn A, van Dooren R, Wyatt L, Leppert IR, Baracchini G, Hughes C, Williams KM, Sylvain E, Tremblay-Mercier J, Poirier J, Villeneuve S, Tardif C, Spreng RN; PREVENT-AD Research Group. Turner GR, et al. Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2322617121. doi: 10.1073/pnas.2322617121. Epub 2024 May 21. Proc Natl Acad Sci U S A. 2024. PMID: 38771873 Free article.
Association of antenatal or neonatal SARS-COV-2 exposure with developmental and respiratory outcomes, and healthcare usage in early childhood: a national prospective cohort study.
Jackson R, Cornish R, Daskalopoulou Z, Gale C, Hurd M, Johnson S, Knight M, Kurinczuk JJ, Woodward K, Chakkarapani E; SINEPOST collaborative group. Jackson R, et al. EClinicalMedicine. 2024 May 3;72:102628. doi: 10.1016/j.eclinm.2024.102628. eCollection 2024 Jun. EClinicalMedicine. 2024. PMID: 38737004 Free PMC article.
1,718 results