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γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis.
Hu B, Jin C, Zeng X, Resch JM, Jedrychowski MP, Yang Z, Desai BN, Banks AS, Lowell BB, Mathis D, Spiegelman BM. Hu B, et al. Among authors: zeng x. Nature. 2020 Feb;578(7796):610-614. doi: 10.1038/s41586-020-2028-z. Epub 2020 Feb 19. Nature. 2020. PMID: 32076265 Free PMC article.
Fat cells directly sense temperature to activate thermogenesis.
Ye L, Wu J, Cohen P, Kazak L, Khandekar MJ, Jedrychowski MP, Zeng X, Gygi SP, Spiegelman BM. Ye L, et al. Among authors: zeng x. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12480-5. doi: 10.1073/pnas.1310261110. Epub 2013 Jul 1. Proc Natl Acad Sci U S A. 2013. PMID: 23818608 Free PMC article.
Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine.
Sun Y, Rahbani JF, Jedrychowski MP, Riley CL, Vidoni S, Bogoslavski D, Hu B, Dumesic PA, Zeng X, Wang AB, Knudsen NH, Kim CR, Marasciullo A, Millán JL, Chouchani ET, Kazak L, Spiegelman BM. Sun Y, et al. Among authors: zeng x. Nature. 2021 May;593(7860):580-585. doi: 10.1038/s41586-021-03533-z. Epub 2021 May 12. Nature. 2021. PMID: 33981039 Free PMC article.
Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.
Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM. Cohen P, et al. Among authors: zeng x. Cell. 2014 Jan 16;156(1-2):304-16. doi: 10.1016/j.cell.2013.12.021. Cell. 2014. PMID: 24439384 Free PMC article.
A smooth muscle-like origin for beige adipocytes.
Long JZ, Svensson KJ, Tsai L, Zeng X, Roh HC, Kong X, Rao RR, Lou J, Lokurkar I, Baur W, Castellot JJ Jr, Rosen ED, Spiegelman BM. Long JZ, et al. Among authors: zeng x. Cell Metab. 2014 May 6;19(5):810-20. doi: 10.1016/j.cmet.2014.03.025. Epub 2014 Apr 4. Cell Metab. 2014. PMID: 24709624 Free PMC article.
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