Hirouchi M - Search Results

1

Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity.

Grandjean JM, Jiu AY, West JW, Aoyagi A, Droege DG, Elepano M, Hirasawa M, Hirouchi M, Murakami R, Lee J, Sasaki K, Hirano S, Ohyama T, Tang BC, Vaz RJ, Inoue M, Olson SH, Prusiner SB, Conrad J, Paras NA. Grandjean JM, et al. Among authors: hirouchi m. ACS Med Chem Lett. 2020 Jan 30;11(2):127-132. doi: 10.1021/acsmedchemlett.9b00480. eCollection 2020 Feb 13. ACS Med Chem Lett. 2020. PMID: 32071678 Free PMC article.

2

Discovery of DS-1558: A Potent and Orally Bioavailable GPR40 Agonist.

Takano R, Yoshida M, Inoue M, Honda T, Nakashima R, Matsumoto K, Yano T, Ogata T, Watanabe N, Hirouchi M, Yoneyama T, Ito S, Toda N. Takano R, et al. Among authors: hirouchi m. ACS Med Chem Lett. 2015 Jan 13;6(3):266-70. doi: 10.1021/ml500391n. eCollection 2015 Mar 12. ACS Med Chem Lett. 2015. PMID: 25815144 Free PMC article.

3

Optimization of 3-aryl-3-ethoxypropanoic acids and discovery of the potent GPR40 agonist DS-1558.

Takano R, Yoshida M, Inoue M, Honda T, Nakashima R, Matsumoto K, Yano T, Ogata T, Watanabe N, Hirouchi M, Kimura T, Toda N. Takano R, et al. Among authors: hirouchi m. Bioorg Med Chem. 2015 Sep 1;23(17):5546-65. doi: 10.1016/j.bmc.2015.07.028. Epub 2015 Jul 23. Bioorg Med Chem. 2015. PMID: 26234904

4

Discovery and optimization of novel fatty acid transport protein 1 (FATP1) inhibitors.

Matsufuji T, Ikeda M, Naito A, Hirouchi M, Takakusa H, Kanda S, Izumi M, Harada J, Shinozuka T. Matsufuji T, et al. Among authors: hirouchi m. Bioorg Med Chem Lett. 2012 Aug 1;22(15):5067-70. doi: 10.1016/j.bmcl.2012.05.130. Epub 2012 Jun 19. Bioorg Med Chem Lett. 2012. PMID: 22749869

5

Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties.

Matsufuji T, Ikeda M, Naito A, Hirouchi M, Kanda S, Izumi M, Harada J, Shinozuka T. Matsufuji T, et al. Among authors: hirouchi m. Bioorg Med Chem Lett. 2013 May 1;23(9):2560-5. doi: 10.1016/j.bmcl.2013.02.116. Epub 2013 Mar 7. Bioorg Med Chem Lett. 2013. PMID: 23528296

6

Discovery of DS-3801b, a non-macrolide GPR38 agonist with N-methylanilide structure.

Toda N, Shida T, Takano R, Katagiri T, Hirouchi M, Abe M, Soma K, Nakagami Y, Yamazaki M. Toda N, et al. Among authors: hirouchi m. Bioorg Med Chem Lett. 2022 Mar 1;59:128554. doi: 10.1016/j.bmcl.2022.128554. Epub 2022 Jan 18. Bioorg Med Chem Lett. 2022. PMID: 35051575

7

Evaluation of the usefulness of breast cancer resistance protein (BCRP) knockout mice and BCRP inhibitor-treated monkeys to estimate the clinical impact of BCRP modulation on the pharmacokinetics of BCRP substrates.

Karibe T, Hagihara-Nakagomi R, Abe K, Imaoka T, Mikkaichi T, Yasuda S, Hirouchi M, Watanabe N, Okudaira N, Izumi T. Karibe T, et al. Among authors: hirouchi m. Pharm Res. 2015 May;32(5):1634-47. doi: 10.1007/s11095-014-1563-4. Epub 2014 Nov 8. Pharm Res. 2015. PMID: 25380981

8

Human pharmacokinetic prediction of UDP-glucuronosyltransferase substrates with an animal scale-up approach.

Deguchi T, Watanabe N, Kurihara A, Igeta K, Ikenaga H, Fusegawa K, Suzuki N, Murata S, Hirouchi M, Furuta Y, Iwasaki M, Okazaki O, Izumi T. Deguchi T, et al. Among authors: hirouchi m. Drug Metab Dispos. 2011 May;39(5):820-9. doi: 10.1124/dmd.110.037457. Epub 2011 Jan 31. Drug Metab Dispos. 2011. PMID: 21282406

9

Integrated approach of in vivo and in vitro evaluation of the involvement of hepatic uptake organic anion transporters in the drug disposition in rats using rifampicin as an inhibitor.

Imaoka T, Mikkaichi T, Abe K, Hirouchi M, Okudaira N, Izumi T. Imaoka T, et al. Among authors: hirouchi m. Drug Metab Dispos. 2013 Jul;41(7):1442-9. doi: 10.1124/dmd.113.051052. Epub 2013 May 2. Drug Metab Dispos. 2013. PMID: 23640987

10

Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4.

Hayashi H, Naoi S, Nakagawa T, Nishikawa T, Fukuda H, Imajoh-Ohmi S, Kondo A, Kubo K, Yabuki T, Hattori A, Hirouchi M, Sugiyama Y. Hayashi H, et al. Among authors: hirouchi m. J Biol Chem. 2012 Apr 27;287(18):15054-65. doi: 10.1074/jbc.M111.337931. Epub 2012 Mar 12. J Biol Chem. 2012. PMID: 22411990 Free PMC article.

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