Grandjean JM - Search Results

1

Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity.

Grandjean JM, Jiu AY, West JW, Aoyagi A, Droege DG, Elepano M, Hirasawa M, Hirouchi M, Murakami R, Lee J, Sasaki K, Hirano S, Ohyama T, Tang BC, Vaz RJ, Inoue M, Olson SH, Prusiner SB, Conrad J, Paras NA. Grandjean JM, et al. ACS Med Chem Lett. 2020 Jan 30;11(2):127-132. doi: 10.1021/acsmedchemlett.9b00480. eCollection 2020 Feb 13. ACS Med Chem Lett. 2020. PMID: 32071678 Free PMC article.

2

Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome.

Griffin AL, Jaishankar P, Grandjean JM, Olson SH, Renslo AR, Baraban SC. Griffin AL, et al. Among authors: grandjean jm. Brain Commun. 2019;1(1):fcz008. doi: 10.1093/braincomms/fcz008. Epub 2019 Aug 1. Brain Commun. 2019. PMID: 31667472 Free PMC article.

3

Amide and amine nucleophiles in polar radical crossover cycloadditions: synthesis of γ-lactams and pyrrolidines.

Gesmundo NJ, Grandjean JM, Nicewicz DA. Gesmundo NJ, et al. Among authors: grandjean jm. Org Lett. 2015 Mar 6;17(5):1316-9. doi: 10.1021/acs.orglett.5b00316. Epub 2015 Feb 19. Org Lett. 2015. PMID: 25695366

4

Synthesis of highly substituted tetrahydrofurans by catalytic polar-radical-crossover cycloadditions of alkenes and alkenols.

Grandjean JM, Nicewicz DA. Grandjean JM, et al. Angew Chem Int Ed Engl. 2013 Apr 2;52(14):3967-71. doi: 10.1002/anie.201210111. Epub 2013 Feb 25. Angew Chem Int Ed Engl. 2013. PMID: 23440762 No abstract available.

5

The direct anti-Markovnikov addition of mineral acids to styrenes.

Wilger DJ, Grandjean JM, Lammert TR, Nicewicz DA. Wilger DJ, et al. Among authors: grandjean jm. Nat Chem. 2014 Aug;6(8):720-6. doi: 10.1038/nchem.2000. Epub 2014 Jul 13. Nat Chem. 2014. PMID: 25054943

6

Divergent Proteome Reactivity Influences Arm-Selective Activation of the Unfolded Protein Response by Pharmacological Endoplasmic Reticulum Proteostasis Regulators.

Kline GM, Paxman RJ, Lin CY, Madrazo N, Yoon L, Grandjean JMD, Lee K, Nugroho K, Powers ET, Wiseman RL, Kelly JW. Kline GM, et al. Among authors: grandjean jmd. ACS Chem Biol. 2023 Aug 18;18(8):1719-1729. doi: 10.1021/acschembio.3c00042. Epub 2023 Jul 31. ACS Chem Biol. 2023. PMID: 37523656 Free PMC article.

7

Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators.

Kline GM, Paxman RJ, Lin CY, Madrazo N, Grandjean JM, Lee K, Nugroho K, Powers ET, Wiseman RL, Kelly JW. Kline GM, et al. Among authors: grandjean jm. bioRxiv [Preprint]. 2023 Jan 17:2023.01.16.524237. doi: 10.1101/2023.01.16.524237. bioRxiv. 2023. PMID: 36712115 Free PMC article. Updated. Preprint.

8

Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis.

Sun S, Wang C, Zhao P, Kline GM, Grandjean JMD, Jiang X, Labaudiniere R, Wiseman RL, Kelly JW, Balch WE. Sun S, et al. Among authors: grandjean jmd. Cell Chem Biol. 2023 Jan 19;30(1):22-42.e5. doi: 10.1016/j.chembiol.2022.12.004. Epub 2023 Jan 10. Cell Chem Biol. 2023. PMID: 36630963 Free PMC article.

9

Mitochondria and Endoplasmic Reticulum Stress in Retinal Organoids from Patients with Vision Loss.

Lee EJ, Diaz-Aguilar MS, Min H, Choi J, Valdez Duran DA, Grandjean JM, Wiseman RL, Kroeger H, Lin JH. Lee EJ, et al. Among authors: grandjean jm. Am J Pathol. 2023 Nov;193(11):1721-1739. doi: 10.1016/j.ajpath.2022.12.002. Epub 2022 Dec 17. Am J Pathol. 2023. PMID: 36535406

10

ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors.

Mesgarzadeh JS, Romine IC, Smith-Cohen EM, Grandjean JMD, Kelly JW, Genereux JC, Wiseman RL. Mesgarzadeh JS, et al. Among authors: grandjean jmd. Cells. 2022 May 17;11(10):1661. doi: 10.3390/cells11101661. Cells. 2022. PMID: 35626697 Free PMC article.

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